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Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats

Overview of attention for article published in BMC Complementary and Alternative Medicine, July 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Good Attention Score compared to outputs of the same age and source (69th percentile)

Mentioned by

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2 tweeters

Citations

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7 Dimensions

Readers on

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17 Mendeley
Title
Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
Published in
BMC Complementary and Alternative Medicine, July 2016
DOI 10.1186/s12906-016-1236-4
Pubmed ID
Authors

Seewaboon Sireeratawong, Kanjana Jaijoy, Parirat Khonsung, Nirush Lertprasertsuk, Kornkanok Ingkaninan

Abstract

Bacopa monnieri is a medicinal plant which has long been used in Ayurvedic medicines to augment brain function and to improve memory. The purpose of our study was to identify and evaluate possible toxic effects of B. monnieri extract in rats by assessing hematological, biochemical, and histopathological parameters. Acute oral toxicity of Bacopa monnieri extract was studied in female rats by giving a single orally administered dose at a level of 5,000 mg/kg. The rats were monitored for toxic signs for 14 days. In the chronic toxicity test, groups of both female and male rats were given daily oral doses of B. monnieri extract at dose levels of either 30, 60, 300 or 1,500 mg/kg for 270 days. The behavior and health of the animals was then monitored. At the end of the observation period, the body and organ weights of the rats in each group were measured. Blood was collected and necropsy was performed to evaluate their hematology, blood clinical chemistry, and microanatomy. The acute toxicity test found no significant differences between the experimental and the control group rats. In the chronic toxicity test, animal behavior and health of the experimental groups were normal, just as in the control rats. All values of other parameters assessed remained within the normal range. A single oral administration of B. monnieri extract at the dose of 5,000 mg/kg did not cause any serious undesirable effects. B. monnieri extract at doses of 30, 60, 300 and 1,500 mg/kg given for 270 days did not produce any toxicity in rats.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 3 18%
Student > Postgraduate 3 18%
Student > Master 2 12%
Student > Bachelor 2 12%
Lecturer 2 12%
Other 5 29%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 3 18%
Medicine and Dentistry 3 18%
Nursing and Health Professions 2 12%
Unspecified 2 12%
Neuroscience 2 12%
Other 5 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2016.
All research outputs
#3,639,744
of 8,148,366 outputs
Outputs from BMC Complementary and Alternative Medicine
#861
of 2,037 outputs
Outputs of similar age
#109,144
of 257,952 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#29
of 94 outputs
Altmetric has tracked 8,148,366 research outputs across all sources so far. This one has received more attention than most of these and is in the 54th percentile.
So far Altmetric has tracked 2,037 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,952 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.