@Bamks_ https://t.co/Mqmr5cYwL8 This actually mentions that bullshit meta analysis you referenced. This is also why I trust little to none of the data you sent. The data on weight gain and increased risk of suicide is extremely limited and doesn’t show a
“Moreover, they say little about hard clinical outcomes and the long-term benefit-harm ratio.” The evidence from clinical trials argument is extremely flawed, and holds no weight. It does not show true antidepressant effectiveness. https://t.co/Mqmr5cYw
Don't let you get tricked, have Confidence in Your Own built-in NN/'NPU' powered scepticism ...👇https://t.co/yTeTwdI8fa https://t.co/fFkAozWrLM
RT @ueafam: #抗うつ薬 の有効性:1,000 件の #RCT から構築された #エビデンス の神話? 2008 #JohnIoannidis @METRICStanford 〜 図1:真の EffectSize=0.20 で各試験ES点推定値の SD=0.20 or…
RT @ueafam: それを指摘したのが #JohnIoannidis であり、真似してミスったのが高野久紀である。 https://t.co/94B9DM2knr https://t.co/B3jPwao4WD
RT @shvogt: @Deedoherty2 @PloederlM @psychgeist52 John Ioannidis comments: 'Telling lies to compete against more unscrupulous producers of…
RT @shvogt: @Deedoherty2 @PloederlM @psychgeist52 John Ioannidis comments: 'Telling lies to compete against more unscrupulous producers of…
RT @shvogt: @Deedoherty2 @PloederlM @psychgeist52 John Ioannidis comments: 'Telling lies to compete against more unscrupulous producers of…
@Deedoherty2 @PloederlM @psychgeist52 John Ioannidis comments: 'Telling lies to compete against more unscrupulous producers of lies in our society is not the way to make scientific progress.' https://t.co/UB5ruwE8EX
RT @shvogt: @Rozewicz @joannamoncrieff Antidepressants do not simply - 'work'. Methodologically informed reality: ‘..suggest antidepressant…
RT @shvogt: @Rozewicz @joannamoncrieff Antidepressants do not simply - 'work'. Methodologically informed reality: ‘..suggest antidepressant…
RT @shvogt: @Rozewicz @joannamoncrieff Antidepressants do not simply - 'work'. Methodologically informed reality: ‘..suggest antidepressant…
RT @shvogt: @Rozewicz @joannamoncrieff Antidepressants do not simply - 'work'. Methodologically informed reality: ‘..suggest antidepressant…
@Rozewicz @joannamoncrieff Antidepressants do not simply - 'work'. Methodologically informed reality: ‘..suggest antidepressants may be less effective than their wide marketing suggests. Short-term benefits are small & long-term balance of benefits &am
このRT例は #JohnIoannidis 論文の趣旨と同義 [https://t.co/6SFqgPxurs]。私のRT画像は「真値=0.25」で約40%(真値からランダム変動する確率分布(薄緑)における両側 P=0.80 だから)の試験が P<0.05 となる例。この添付画像の方は「真値=0.50」だが、それを 0.25 にすれば同じことを表してる。 https://t.co/J5B2QVX4HL
RT @ueafam: #抗うつ薬 の有効性:1,000 件の #RCT から構築された #エビデンス の神話? 2008 #JohnIoannidis @METRICStanford 〜 図1:真の EffectSize=0.20 で各試験ES点推定値の SD=0.20 or…
「効果ゼロの薬剤がαエラーで有効性を示した」ではないとしても、ランダム割当による偏りで効果量が誇張されてることも #JohnIoannidis が解説した[https://t.co/94B9DM2knr]。
RT @ueafam: #抗うつ薬 の有効性:1,000 件の #RCT から構築された #エビデンス の神話? 2008 #JohnIoannidis @METRICStanford 〜 図1:真の EffectSize=0.20 で各試験ES点推定値の SD=0.20 or…
RT @ueafam: それを指摘したのが最も賢い #JohnIoannidis であり、 https://t.co/94B9DM2knr
RT @ueafam: それを指摘したのが #JohnIoannidis であり、真似してミスったのが高野久紀である。 https://t.co/94B9DM2knr https://t.co/B3jPwao4WD
@VPrasadMDMPH @BretWeinstein You’re getting sidetracked by the EAU. You need to address the points about the RCT because there’s never been examples of manipulated trials to get the conclusions they want…right?https://t.co/TFYo3orpX2
それを指摘したのが #JohnIoannidis であり、真似してミスったのが高野久紀である。 https://t.co/94B9DM2knr https://t.co/B3jPwao4WD
それを指摘したのが最も賢い #JohnIoannidis であり、 https://t.co/94B9DM2knr
@thatsfunnymel @ChrisSheltonMsc @DrMcFillin One example is this: https://t.co/2XTCSwu1og
RT @ueafam: #抗うつ薬 の有効性:1,000 件の #RCT から構築された #エビデンス の神話? 2008 #JohnIoannidis @METRICStanford 〜 図1:真の EffectSize=0.20 で各試験ES点推定値の SD=0.20 or…
RT @ueafam: 抗うつ薬の有効性:千のランダム化試験から構築された証拠神話? 2008 #JohnIoannidis #スタンフォード大学 教授 試験の半数が公式に有効であったが、公開された報告は殆ど遍在的に有意な結果を主張した。『否定的』試験結果は未発表か『肯定的』結…
@AVEON1917 @AngieDejong @apmassaro3 Very expensive placebo with grotesque side effects, only used as a frontline treatment for depression in the US due to complete regulatory capture of the FDA https://t.co/KlX33huQtd
"In severe major depression, antidepressants did not become more effective, simply placebo lost effectiveness." https://t.co/1TcprF5pHT This was a great article. If you are depressed, please, do not try these garbage drugs. SSRIs or SNRIs are dangerous. Th
これ RT と同じこと。 https://t.co/94B9DM2knr
Like, the single-most prescribed MH med (SSRIs) essentially work as well as a Snickers. OTOH, the main treatment for addiction (#1 MH emergency)? Join a religious cult formed in the 1930s.. https://t.co/fLScPlQS10
この画像を、真値 d=0.50 から 0.20 へ変更し、バラツキ程度を3パターンにしたものであろう。 https://t.co/MNyFciD4YT
#抗うつ薬 の有効性:1,000 件の #RCT から構築された #エビデンス の神話? 2008 #JohnIoannidis @METRICStanford 〜 図1:真の EffectSize=0.20 で各試験ES点推定値の SD=0.20 or 0.40 or 0.60 との仮定での、医薬品承認された国における試験毎 ES の予想平均値と範囲 〜 https://t.co/6SFqgPxurs https://t.co/4wIgIFdGxA
@OscarSkeptic @PhilJenkins_ @DrAseemMalhotra Oh yeah antidepressants are also BS https://t.co/4thZJQ1Kps
@RupaliChadhaMD Well, the end is in the beginning. Scientists don't even know if antidepressants work or how they work. The commonly repeated premise that an increase in serotonin and or other brain chemicals cures depression has never been proven: https
@kimmurphy100 @NoahCoo87276392 @Popehat It's a fair question. SSRIs are moderately helpful for moderate & major depression, and have a raft of side effects, including metabolic & sexual disturbances. Serotonin studies are inconclusive. https://t.
RT @ueafam: 抗うつ薬の有効性:千のランダム化試験から構築された証拠神話? 2008 #JohnIoannidis #スタンフォード大学 教授 試験の半数が公式に有効であったが、公開された報告は殆ど遍在的に有意な結果を主張した。『否定的』試験結果は未発表か『肯定的』結…
@itsmegandamnit @BrandonSnass @opinion You are so closed minded that you have missed the entire point. Why are you so rude? If you don't want to believe it, you won't. I go with the facts, science, proven testing, and not with the fake big pharma bs. http
Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials? https://t.co/7x1gd3xsPN
@mcintosh2001 @joannamoncrieff @rustyrockets 😂 How much do you get paid per tweet? Clinical trials, my ass. https://t.co/pzj9SKALSW
@TizzyEnt Didn’t we just find out that there’s no proof SSRIs work as they are supposed to? https://t.co/Zl868hlCkA they studied it for years. 🤷🏻♀️
@Deedoherty2 @jack_turban I was actually doing some googling and reading. Specifically for the SSRI's don't save lives (I googled his direct quote on that). Very interesting, this one for instance: https://t.co/nfUHLjzG5d. While it raises important questio
@NaudetFlorian Even John Ioannidis was confuses https://t.co/aB80ZLiqtv
@RealDoctorMike, I was always thought to believe chemical imbalances the cause of many mental illnesses, but now there appears to be evidence to suggest otherwise. Any thoughts on this publishing? https://t.co/Iv0YuayoIH
@jmicrobe9 @SimonsonMolly @LieblichSam @BodhiWeaver “antidepressants may be less effective than their wide marketing suggests due to the use of many small randomized trials with clinically non-relevant outcomes, improper interpretation of statistical signi
This is from 2008! Why is it suddenly news?!? 🧐 Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials? https://t.co/JHQ2HDXraX
RT @JulianAndrew63: @barnabyheaton It's been called the medicalisation of misery: https://t.co/ENiJT8zRXx A good outline is provided in th…
RT @JulianAndrew63: @barnabyheaton It's been called the medicalisation of misery: https://t.co/ENiJT8zRXx A good outline is provided in th…
RT @JulianAndrew63: @barnabyheaton It's been called the medicalisation of misery: https://t.co/ENiJT8zRXx A good outline is provided in th…
@barnabyheaton It's been called the medicalisation of misery: https://t.co/ENiJT8zRXx A good outline is provided in this book: https://t.co/bXAwISPKzI But hey it makes for a record-breaking profits - even if most of what we are told about the meds is BS:
@jimsilpeg @michaeljknowles I took SSRIs myself decades ago; experienced suicidal ideation & greatly increased aggression firsthand. In addition to causing these known dangerous psychological changes, there is little evidence SSRIs improve mental healt
@MamaWerewolf13 Here is some research https://t.co/TkzD4h5MAy
@javelinhands @jurigagarini @johhsmith606 @biboofficial on general ineffectiveness; https://t.co/RWO1x2IJTW https://t.co/9CPyronbkw https://t.co/zoejfskK20 on worsening outcomes; https://t.co/BbPZ4d3xzH https://t.co/LJEz55ZS8v https://t.co/k0guf7iE5A http
RT @dawso007: @awaisaftab For comparison - here is Ioannidis comments from 13 years ago: https://t.co/5yibWcLkF6
RT @dawso007: @awaisaftab For comparison - here is Ioannidis comments from 13 years ago: https://t.co/5yibWcLkF6
@awaisaftab For comparison - here is Ioannidis comments from 13 years ago: https://t.co/5yibWcLkF6
@DpAngst i highly recommend reading this by Ioannidis https://t.co/HSLlTIhe9u "Nevertheless, even if one feels a bit depressed by this state of affairs, there is no reason to take antidepressants, they probably won't work" I would choose placebo over ant
@cortatija i don’t have the paper saved that found this (i’ll keep looking) but here are some to get you started: https://t.co/R00ruJp4PB https://t.co/v8tmc32tUb https://t.co/ay7V5pO62k https://t.co/kPJENUW4ib
@ProfRobHoward Anti-depressants are hyped as beneficial for mental health, on the basis of poor evidence. https://t.co/o5trQOuAa4
RT @KirkegaardEmil: 😎 "This may sound depressing for the current state of clinical trials research on antidepressants and beyond. Neverthel…
RT @KirkegaardEmil: 😎 "This may sound depressing for the current state of clinical trials research on antidepressants and beyond. Neverthel…
RT @KirkegaardEmil: 😎 "This may sound depressing for the current state of clinical trials research on antidepressants and beyond. Neverthel…
RT @KirkegaardEmil: 😎 "This may sound depressing for the current state of clinical trials research on antidepressants and beyond. Neverthel…
😎 "This may sound depressing for the current state of clinical trials research on antidepressants and beyond. Nevertheless, even if one feels a bit depressed by this state of affairs, there is no reason to take antidepressants, they probably won't work."
This kind of thing is not new at all. https://t.co/w98g8dj8WW
RT @HenryRunamucker: @recover2renew "Outside of mainstream medicine..." Except for, you know, some of the most cited medical researchers of…
RT @HenryRunamucker: @recover2renew "Outside of mainstream medicine..." Except for, you know, some of the most cited medical researchers of…
@recover2renew "Outside of mainstream medicine..." Except for, you know, some of the most cited medical researchers of all time: https://t.co/KlFQ56iD7h
...the risk/benefit ratio was more favorable. But the randomized controlled trials (RCTs) for antidepressants were of much higher quality than the ECT research. Fewer glaring confounds and much larger sample sizes. https://t.co/KlFQ56iD7h
RT @e7a4f6: 抗うつ薬の有効性:千のランダム化試験から構築された証拠神話? 2008 #JohnIoannidis #スタンフォード大学 教授 試験の半数が公式に有効であったが、公開された報告は殆ど遍在的に有意な結果を主張した。『否定的』試験結果は未発表か『肯定的』結…
統計学的有意性と臨床的有意性:#イギリス国立医療技術評価機構 (NICE) のコンセンサスとして臨床的有意な効果を主張するには #EffectSize = 0.50 または #ハミルトン抑うつ評価尺度 (#HDRS #HAMD) で3点以上の群間差が必要であることが示唆された。 https://t.co/hdrNeTkWnk
統計学的有意性と臨床的有意性:〜 典型的には #ハミルトン抑うつ評価尺度 (#HDRS=#HAMD) などの #抑うつ尺度 である。このような連続的な転帰は、僅かな差異であっても、形式的に #統計学的有意差 (P<0.05) を示す。#統計学的有意性 は #臨床的有意性 と混同されている。 https://t.co/hdrNeTkWnk
@BMJ_Open @CochraneNordic #出版バイアス:#オックスフォード大学 #京都大学 教授らにより報告されたNWメタ解析は[https://t.co/mkPAuSxBu9]、公開された研究 436 件と、公開されなかった研究 86 件を含めたが、1,000 件もの #抗うつ薬 の研究が行われた可能性がある[https://t.co/REMIHsuzKK]。 https://t.co/7pCAQXu1RF
抗うつ薬の有効性:千のランダム化試験から構築された証拠神話? 2008 #JohnIoannidis #スタンフォード大学 教授 試験の半数が公式に有効であったが、公開された報告は殆ど遍在的に有意な結果を主張した。『否定的』試験結果は未発表か『肯定的』結果を示すために曲解された。 https://t.co/REMIHsuzKK https://t.co/5sKi6ENIhb
RT @HengartnerMP: @dailyzad Interestingly, 10 years ago Ioannidis published a piece that is pretty much in line with Gotzsche and which may…
@BMJ_Open @CochraneNordic #抗うつ薬 の試験には多くの方法論的な制限があり[https://t.co/UbjxrSrA0Z]、その多くは数十年に渡り認められてきた[https://t.co/REMIHsuzKK]。#オックスフォード大学 #京都大学 教授らにより報告されたメタ解析結果の #方法論的制限 を検証する[https://t.co/mkPAuSxBu9]。 https://t.co/7pCAQXu1RF
@MECFSNews @StenHelmfrid i didn't manage to read this today, but it may be of interest: https://t.co/RoDitE8InF
RT @StephFarrel: @AllenFrancesMD Recent studies also question effectiveness of antidepressants which has been vastly overstated due to desi…
@AllenFrancesMD Recent studies also question effectiveness of antidepressants which has been vastly overstated due to design and publication bias. Antidepressants are also not without significant harms. https://t.co/dEXUh746xD
RT @dawso007: @eturnermd1 Thanks - already read it. I recruited (as an editor) him to give one of the original papers doubting the effects…
@eturnermd1 Thanks - already read it. I recruited (as an editor) him to give one of the original papers doubting the effects of ADs and now he is in meta-analyses that supports the effect. Go figure. https://t.co/WCk7X4ODFr
@RaulVicenteJ @eparquiodelgado @Rderoty @TannedBallsU De todos modos mira, entiendo que Google es difícil. Mira, una revisión de Ioannidis: https://t.co/aMpF40IsT1
@JeanAlexanian @sevelaure C'est peut-être tout de même un peu excessif, ça. J'ai plutôt l'impression qu'ils exemplifient à merveille à peu près tout ce qui dysfonctionne dans la recherche clinique moderne... 😅 https://t.co/Su1w2oMfJg
i mean: https://t.co/UQ0wpL0LSy if you're going to use the knee-jerk "but science" reaction against this woman maybe spend a minute reading on the actual scientific consensus which is decidedly "meh" on antidepressants
RT @zeephyyr: @DrLindsayWu Ioannidis JPA. “Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials…
@DrLindsayWu Ioannidis JPA. “Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials?” Philos Ethics Humanit Med (2008 May 27) vol. 3 art. 14 DOI: 10.1186/1747-5341-3-14 https://t.co/aiS7jVibcv https://t.co/QeqViPfq
@smith_valence @AllegroRubato @LTF_01 @RealYeyoZa @Anthrofuentes Anti depressants just don t work that much on anybody. https://t.co/d5tWIfesKf https://t.co/vLaiYg48rf So no need to make additional ad hoc stuff on them.
@CiViX @MagnusNome @NormalNorway @BedrocanInfo Så da har du vel flere bloggposter å vise til hvor du krever at smertemeds og hostesaft fjernes fra markedet da, eller? Når det gjelder evidens eller mangel på sådan stoler jeg mer på forskere enn på bloggere
@piliymili69 @tombcn @BeatrizTalegon @elespanolcom De lo que albergo pocas dudas es de que el "tratamiento" homeopático contra la depresión es más seguro y como mínimo tan eficaz como el tratamiento habitualmente prescrito por la medicina oficial: https://
RT @zeephyyr: @maldita_ciencia ¿Cuántas "terapias" q hoy se consideran "científicas" serán pseudoterapias en un futuro? P.ej. el tratamient…
@maldita_ciencia ¿Cuántas "terapias" q hoy se consideran "científicas" serán pseudoterapias en un futuro? P.ej. el tratamiento con antidepresivos tipo SSRI (ej. Prozac):https://t.co/aiS7jVibcv ¿Cuántos suicidios (en su mayoría d depresivos) hay en Españist
RT @HengartnerMP: @dailyzad Interestingly, 10 years ago Ioannidis published a piece that is pretty much in line with Gotzsche and which may…
@dailyzad Interestingly, 10 years ago Ioannidis published a piece that is pretty much in line with Gotzsche and which may have influenced Gotzsches later work on antidepressants. Ioannidis himself claimed that the effectiveness of antidepressants likely is
You have a lot of growing up to do, @LayVegan. https://t.co/DYed2W0EA6 Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials? John PA Ioannidis. Philos Ethics Humanit Med. 2008; 3: 14. DOI: 10.1186/1747-5341-3-1