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Lipid profiles in schizophrenia associated with clinical traits: a five year follow-up study

Overview of attention for article published in BMC Psychiatry, August 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)

Mentioned by

5 tweeters


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Readers on

33 Mendeley
Lipid profiles in schizophrenia associated with clinical traits: a five year follow-up study
Published in
BMC Psychiatry, August 2016
DOI 10.1186/s12888-016-1006-3
Pubmed ID

Dag K. Solberg, Håvard Bentsen, Helge Refsum, Ole A. Andreassen


Alterations in serum and membrane lipids may be involved in schizophrenia pathophysiology. It is not known whether lipid profiles are associated with disease severity or current symptom level. Clinical and lipid data were gathered from 55 patients with schizophrenia admitted to psychiatric emergency wards in an acute stage of the disease (T1). The patients were re-examined after 5 years at a stable phase (T2). The clinical assessments included Positive and Negative Syndrome Scale (PANSS total, positive, negative) and Global Assessment of Functioning (GAF S, symptom and F, function). Serum lipids (cholesterol and triglyceride) and membrane polyunsaturated fatty acids (PUFA, LCPUFA) were measured. Healthy controls were recruited among hospital workers. Serum triglyceride was significantly higher in patients with schizophrenia compared to healthy controls both at T1 and T2 (p < 0.001), while serum cholesterol did not differ significantly. The levels of serum lipids in patients remained stable over time. At T1, serum lipids and symptoms were not significantly correlated. At T2, higher serum lipids were associated with more severe symptoms and poorer functioning. Higher serum lipid levels at T1 were associated with more severe symptoms and poorer functioning at T2; cholesterol with GAF-S (p < 0.05), triglyceride with PANSS total (p < 0.05), GAF-S (p < 0.01) and GAF-F (p < 0.01). Membrane lipids were significantly lower in the patient group compared to healthy controls at T1 (PUFA p < 0.001, LCPUFA p < 0.001), but not at T2. Membrane lipids were not significantly correlated with symptoms at T1, but significantly associated with negative symptoms and functioning at T2 as previously reported. The present findings suggest different roles of membrane and serum lipids in schizophrenia pathophysiology. To further elucidate the relation of lipid biology to disease traits, replication in independent studies of longitudinal samples are warranted.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Egypt 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 18%
Researcher 5 15%
Student > Bachelor 5 15%
Student > Postgraduate 4 12%
Student > Ph. D. Student 4 12%
Other 7 21%
Unknown 2 6%
Readers by discipline Count As %
Medicine and Dentistry 9 27%
Neuroscience 7 21%
Biochemistry, Genetics and Molecular Biology 3 9%
Agricultural and Biological Sciences 2 6%
Psychology 2 6%
Other 6 18%
Unknown 4 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2016.
All research outputs
of 13,502,662 outputs
Outputs from BMC Psychiatry
of 3,140 outputs
Outputs of similar age
of 264,784 outputs
Outputs of similar age from BMC Psychiatry
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Altmetric has tracked 13,502,662 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,140 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,784 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them