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Epilepsy as a risk factor for hepatic encephalopathy in patients with cirrhosis: a cohort study

Overview of attention for article published in BMC Gastroenterology, July 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
3 Dimensions

Readers on

mendeley
19 Mendeley
Title
Epilepsy as a risk factor for hepatic encephalopathy in patients with cirrhosis: a cohort study
Published in
BMC Gastroenterology, July 2016
DOI 10.1186/s12876-016-0487-3
Pubmed ID
Authors

Peter Jepsen, Jakob Christensen, Karin Weissenborn, Hugh Watson, Hendrik Vilstrup

Abstract

Epilepsy is associated with an increased mortality among cirrhosis patients, but the reasons are unknown. We aimed to determine whether epilepsy is a risk factor for developing hepatic encephalopathy (HE), which is a strong predictor of mortality. We used data from three randomized 1-year trials of satavaptan in cirrhosis patients with ascites. With Cox regression, we compared the hazard rates of HE grade 1-4 between those cirrhosis patients who did or did not have epilepsy. We adjusted for confounding by gender, age, cirrhosis etiology, diabetes, history of HE, Model for Endstage Liver Disease (MELD) score, serum sodium, albumin, lactulose use, rifaximin use, and benzodiazepine/barbiturate sedation. In a supplementary analysis we examined the association between epilepsy and the hazard rate of HE grade 2-4. Of the 1120 cirrhosis patients with ascites, 21 (1.9 %) were diagnosed with epilepsy. These patients had better liver function at inclusion than the patients without epilepsy (median MELD score 7.9 vs. 11.4), and only one died during the trials. Nevertheless, seven patients with epilepsy had an HE episode during the follow-up, and the adjusted hazard ratio of HE grade 1-4 for patients with epilepsy vs. controls was 2.12 (95 % CI 0.99-4.55). The corresponding hazard ratio of HE grade 2-4 was 3.83 (95 % CI 1.65-8.87). Our findings suggest that epilepsy is associated with an increased risk of HE in patients with cirrhosis.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 26%
Researcher 2 11%
Student > Bachelor 2 11%
Professor > Associate Professor 2 11%
Student > Ph. D. Student 1 5%
Other 3 16%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 8 42%
Agricultural and Biological Sciences 1 5%
Nursing and Health Professions 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Neuroscience 1 5%
Other 0 0%
Unknown 7 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2016.
All research outputs
#1,205,493
of 8,282,830 outputs
Outputs from BMC Gastroenterology
#79
of 694 outputs
Outputs of similar age
#53,257
of 252,698 outputs
Outputs of similar age from BMC Gastroenterology
#5
of 23 outputs
Altmetric has tracked 8,282,830 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 694 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,698 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.