| Title |
Adult reversal of cognitive phenotypes in neurodevelopmental disorders
|
|---|---|
| Published in |
Journal of Neurodevelopmental Disorders, June 2009
|
| DOI | 10.1007/s11689-009-9018-7 |
| Pubmed ID | |
| Authors |
Alcino J. Silva, Dan Ehninger |
| Abstract |
Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irreparable in adults, were believed to underlie the neurological and psychiatric phenotypes of a range of common mental health problems with a clear developmental component. As a consequence, most researchers have focused their efforts on understanding the molecular and cellular processes that alter development with the hope that early intervention could prevent the emergent pathology. Unexpectedly, several different animal model studies published recently, including animal models of autism, suggest that it may be possible to reverse neurodevelopmental disorders in adults: Addressing the underlying molecular and cellular deficits in adults could in several cases dramatically improve the neurocognitive phenotypes in these animal models. The findings reviewed here provide hope to millions of individuals afflicted with a wide range of neurodevelopmental disorders, including autism, since they suggest that it may be possible to treat or even cure them in adults. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Netherlands | 2 | 3% |
| Portugal | 1 | 1% |
| Italy | 1 | 1% |
| Poland | 1 | 1% |
| Unknown | 72 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 26% |
| Student > Ph. D. Student | 17 | 21% |
| Professor | 7 | 9% |
| Other | 5 | 6% |
| Student > Postgraduate | 5 | 6% |
| Other | 15 | 19% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 36% |
| Neuroscience | 12 | 15% |
| Medicine and Dentistry | 11 | 14% |
| Psychology | 5 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 8 | 10% |
| Unknown | 13 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2020.
All research outputs
#13,144,960
of 22,694,633 outputs
Outputs from Journal of Neurodevelopmental Disorders
#309
of 475 outputs
Outputs of similar age
#90,700
of 110,537 outputs
Outputs of similar age from Journal of Neurodevelopmental Disorders
#6
of 7 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 475 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.