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Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls

Overview of attention for article published in BMC Neuroscience, January 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

twitter
1 tweeter
patent
2 patents

Citations

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84 Dimensions

Readers on

mendeley
89 Mendeley
Title
Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls
Published in
BMC Neuroscience, January 2011
DOI 10.1186/1471-2202-12-13
Pubmed ID
Authors

Marcella Reale, Antonia Patruno, Maria A De Lutiis, Mirko Pesce, Mario Felaco, Massimo Di Giannantonio, Marta Di Nicola, Alfredo Grilli

Abstract

The exact cause of schizophrenia is not known, although several aetiological theories have been proposed for the disease, including developmental or neurodegenerative processes, neurotransmitter abnormalities, viral infection and immune dysfunction or autoimmune mechanisms. Growing evidence suggests that specific cytokines and chemokines play a role in signalling the brain to produce neurochemical, neuroendocrine, neuroimmune and behavioural changes. A relationship between inflammation and schizophrenia was supported by abnormal cytokines production, abnormal concentrations of cytokines and cytokine receptors in the blood and cerebrospinal fluid in schizophrenia. Since the neuropathology of schizophrenia has recently been reported to be closely associated with microglial activation we aimed to determined whether spontaneous or LPS-induced peripheral blood mononuclear cell chemokines and cytokines production is dysregulated in schizophrenic patients compared to healthy subjects. We enrolled 51 untreated first-episode schizophrenics (SC) and 40 healthy subjects (HC) and the levels of MCP-1, MIP-1α, IL-8, IL-18, IFN-γ and RANTES were determined by Elisa method in cell-free supernatants of PBMC cultures.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 1%
United Kingdom 1 1%
New Zealand 1 1%
Mexico 1 1%
United States 1 1%
Unknown 84 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 20%
Researcher 13 15%
Student > Master 12 13%
Student > Doctoral Student 9 10%
Student > Bachelor 6 7%
Other 14 16%
Unknown 17 19%
Readers by discipline Count As %
Medicine and Dentistry 20 22%
Agricultural and Biological Sciences 16 18%
Neuroscience 11 12%
Psychology 7 8%
Biochemistry, Genetics and Molecular Biology 6 7%
Other 5 6%
Unknown 24 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 December 2014.
All research outputs
#4,866,091
of 17,360,236 outputs
Outputs from BMC Neuroscience
#257
of 1,132 outputs
Outputs of similar age
#65,625
of 255,483 outputs
Outputs of similar age from BMC Neuroscience
#12
of 80 outputs
Altmetric has tracked 17,360,236 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,132 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,483 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.