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Treatment of allergic rhinitis with acupoint herbal plaster: an oligonucleotide chip analysis

Overview of attention for article published in BMC Complementary and Alternative Medicine, November 2016
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Title
Treatment of allergic rhinitis with acupoint herbal plaster: an oligonucleotide chip analysis
Published in
BMC Complementary and Alternative Medicine, November 2016
DOI 10.1186/s12906-016-1418-0
Pubmed ID
Authors

Horng-Sheng Shiue, Yun-Shien Lee, Chi-Neu Tsai, Hen-Hong Chang

Abstract

Allergic rhinitis is regarded as an imbalanced Th1/Th2 cell-mediated response. The present study used microarray analysis to compare gene expression levels between allergic rhinitis patients before and after a series of acupoint herbal plaster applications. In this experimental pilot study, volunteers experiencing sneezing, runny nose, and congestion for more than 9 months in the year following initial diagnoses were included after diagnostic confirmation by otolaryngologists to exclude patients with sinusitis and nasal polyps. Patients with persistent allergic rhinitis each received four acupoint herbal plaster treatments applied using the moxibustion technique. Clinical outcomes were evaluated using the Rhinitis Quality of Life Questionnaire (RQLQ). Peripheral blood samples were analyzed using an ImmunoCAP Phadiatop test, and patients were classified as phadiatop (Ph)-positive or -negative. Microarray results were analyzed for genes that were differentially expressed between (1) Ph-positive and -negative patients treated with herbal plaster; and (2) before and after herbal plaster treatment in the Ph-positive patient group. Unsupervised and supervised methods were used for gene-expression data analysis. Nineteen Ph-positive and four Ph-negative participants with persistent allergic rhinitis were included in the study. RQLQ results indicated that the 19 Ph-positive volunteers experienced improvement in six of seven categories following acupoint herbal plaster treatments, whereas the four Ph-negative participants reported improvement in only two categories. Hierarchical clustering and principle component analysis of the gene expression profiles of Ph-positive and -negative participants indicated the groups exhibited distinct physiological responses to acupoint herbal treatment. Evaluation of gene networks using MetaCore identified that the "Immune response_IL-13 signaling via JAK-STAT" and the "Inflammation_Interferon signaling" were down- and up-regulated, respectively, among Ph-positive subjects. In this preliminary study, we find that the IL-13 immune response via JAK-STAT signaling and interferon inflammation signaling were down- and upregulated, respectively, in the Ph-positive group. Further studies are required to verify these pathways in Ph-positive patients, and to determine the mechanism of such pathway dysregulation. ClinicalTrials.gov: NCT02486159 . Registered 30 Jun 2015.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Portugal 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 17%
Student > Master 5 17%
Unspecified 4 13%
Other 4 13%
Student > Postgraduate 3 10%
Other 9 30%
Readers by discipline Count As %
Medicine and Dentistry 17 57%
Unspecified 5 17%
Biochemistry, Genetics and Molecular Biology 3 10%
Agricultural and Biological Sciences 2 7%
Nursing and Health Professions 2 7%
Other 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2016.
All research outputs
#7,475,218
of 8,619,738 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,810
of 2,155 outputs
Outputs of similar age
#197,054
of 241,526 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#34
of 51 outputs
Altmetric has tracked 8,619,738 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,155 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,526 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.