| Title |
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study
|
|---|---|
| Published in |
BMC Infectious Diseases, November 2004
|
| DOI | 10.1186/1471-2334-4-50 |
| Pubmed ID | |
| Authors |
Johan Van Weyenbergh, Gisélia Santana, Argemiro D'Oliveira, Anibal F Santos, Carlos H Costa, Edgar M Carvalho, Aldina Barral, Manoel Barral-Netto |
| Abstract |
The process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency decreases Th1 but not Th2 immune response. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite. |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | 1% |
| Mexico | 1 | 1% |
| France | 1 | 1% |
| Morocco | 1 | 1% |
| Unknown | 67 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 17% |
| Student > Master | 12 | 17% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Bachelor | 7 | 10% |
| Student > Doctoral Student | 4 | 6% |
| Other | 11 | 15% |
| Unknown | 16 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 23% |
| Medicine and Dentistry | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
| Immunology and Microbiology | 4 | 6% |
| Other | 8 | 11% |
| Unknown | 18 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2010.
All research outputs
#6,003,979
of 23,668,780 outputs
Outputs from BMC Infectious Diseases
#1,803
of 7,885 outputs
Outputs of similar age
#27,726
of 143,714 outputs
Outputs of similar age from BMC Infectious Diseases
#5
of 9 outputs
Altmetric has tracked 23,668,780 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 7,885 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,714 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.