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Protective effect of genistein on radiation-induced intestinal injury in tumor bearing mice

Overview of attention for article published in BMC Complementary and Alternative Medicine, May 2013
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  • Good Attention Score compared to outputs of the same age (72nd percentile)

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4 tweeters
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3 Facebook pages

Citations

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27 Mendeley
Title
Protective effect of genistein on radiation-induced intestinal injury in tumor bearing mice
Published in
BMC Complementary and Alternative Medicine, May 2013
DOI 10.1186/1472-6882-13-103
Pubmed ID
Authors

Tae Gen Son, Eun Ji Gong, Min Ji Bae, Sung Dae Kim, Kyu Heo, Changjong Moon, Kwangmo Yang, Joong Sun Kim

Abstract

BACKGROUND: Radiation therapy is the most widely used treatment for cancer, but it causes the side effect of mucositis due to intestinal damage. We examined the protective effect of genistein in tumor-bearing mice after abdominal irradiation by evaluation of apoptosis and intestinal morphological changes. METHODS: Mouse colon cancer CT26 cells were subcutaneously injected at the flank of BALB/c mice to generate tumors. The tumor-bearing mice were treated with abdominal radiation at 5 and 10 Gy, and with genistein at 200 mg/kg body weight per day for 1 d before radiation. The changes in intestinal histology were evaluated 12 h and 3.5 d after irradiation. To assess the effect of the combination treatment on the cancer growth, the tumor volume was determined at sacrifice before tumor overgrowth occurred. RESULTS: Genistein significantly decreased the number of apoptotic nuclei compared with that in the irradiation group 12 h after 5 Gy irradiation. Evaluation of histological changes showed that genistein ameliorated intestinal morphological changes such as decreased crypt survival, villus shortening, and increased length of the basal lamina 3.5 d after 10 Gy irradiation. Moreover, the genistein-treated group exhibited more Ki-67-positive proliferating cells in the jejunum than the irradiated control group, and crypt depths were greater in the genistein-treated group than in the irradiated control group. The mean weight of the CT26 tumors was reduced in the group treated with genistein and radiation compared with the control group. CONCLUSION: Genistein had a protective effect on intestinal damage induced by irradiation and delayed tumor growth. These results suggest that genistein is a useful candidate for preventing radiotherapy-induced intestinal damage in cancer patients.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 4%
Pakistan 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 33%
Unspecified 4 15%
Student > Ph. D. Student 3 11%
Professor > Associate Professor 3 11%
Student > Postgraduate 2 7%
Other 6 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 30%
Unspecified 7 26%
Medicine and Dentistry 6 22%
Biochemistry, Genetics and Molecular Biology 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 1 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2015.
All research outputs
#3,593,335
of 13,035,878 outputs
Outputs from BMC Complementary and Alternative Medicine
#753
of 2,622 outputs
Outputs of similar age
#40,040
of 148,901 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#1
of 1 outputs
Altmetric has tracked 13,035,878 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,622 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 148,901 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them