Title |
Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivoeffects on migration capacity and tumor growth
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Published in |
BMC Medicine, May 2013
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DOI | 10.1186/1741-7015-11-139 |
Pubmed ID | |
Authors |
Carolina Belmar-Lopez, Gracia Mendoza, Daniel Oberg, Jerome Burnet, Carlos Simon, Irene Cervello, Maite Iglesias, Juan Carlos Ramirez, Pilar Lopez-Larrubia, Miguel Quintanilla, Pilar Martin-Duque |
Abstract |
Mesenchymal stem cells (MSCs) have been promoted as an attractive option to use as cellular delivery vehicles to carry anti-tumor agents, owing to their ability to home into tumor sites and secrete cytokines. Multiple isolated populations have been described as MSCs, but despite extensive in vitro characterization, little is known about their in vivo behavior.The aim of this study was to investigate the efficacy and efficiency of different MSC lineages derived from five different sources (bone marrow, adipose tissue, epithelial endometrium, stroma endometrium, and amniotic membrane), in order to assess their adequacy for cell-based anti-tumor therapies. Our study shows the crucial importance of understanding the interaction between MSCs and tumor cells, and provides both information and a methodological approach, which could be used to develop safer and more accurate targeted therapeutic applications. |
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