Thinking about Bayesian trials, trials in rare conditions, etc, are there public repositories of data as it accrued from multiple large trials? Keep thinking back to FEAST and this excellent paper by members of the DSMB. https://t.co/EzxOCAwzOk [1/2]
@GynaeResearcher @sim0ngates Sounds a lot like the FEAST trial https://t.co/Sbeuc41W2Y
@kennethbaillie I think this editorial by the IDMC on the FEAST study is instructive https://t.co/sqyf1BSMhe
@gpollara @sanjaybhagani @BNadjm @Dr_J_Underwood @tmorris_mrc @statsepi @AstraZeneca I just think it is a shame it was stopped early! The risks of stopping early for benefit are well described, e.g. https://t.co/sqyf1BSerG.
@DrToddLee Reminds me of this paper on the FEAST trial - nearly always a bad idea to stop early for benefit https://t.co/1lXUWqiXit
@DrToddLee @dr_michaelmarks @Dr_J_Underwood @FranciscoMarty_ @dr_luke_moore @Grampospath @drnickeasom @Cortes_Penfield @onisillos @ThwaitesGuy I always get spooked by this paper - https://t.co/1lXUWqiXit. I wish there was more money for people to run large
Stopping early because novel treatment arm seems beneficial is seriously problematic. 6 vs 0 deaths, with two of the deaths occurring in patients with stage 4 lung cancer. See Figure 2 in this paper - https://t.co/E3dhhUQIDD. We still have equipoise and sh
RT @sgdambrauskas: 9/19 Got it? And this was indeed a very well designed study. The authors taught us how to perform a randomized controll…
@pedrodammert @Fluid_Academy @NEJM Not agree. Unethical is still reccomending fluid boluses in the clinical scenario where #feast was made. See this author's paper about ethical issues in the RCT https://t.co/QUdQ1b1Uz9
This paper by the FEAST IDMC is fascinating and challenging https://t.co/80cXgSOgto (1/2)
See http://t.co/b0GsF3Zweu on the description of the FEAST Trial.
@MDaware @DocOnSkis @rfdsdoc @TessaRDavis Read. Feast stopped (harm) http://t.co/lphTNujyz9 Stop-it 1 http://t.co/5vy2dcKTCR