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The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

Overview of attention for article published in Acta Neuropathologica Communications, July 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter
patent
6 patents

Citations

dimensions_citation
125 Dimensions

Readers on

mendeley
191 Mendeley
Title
The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease
Published in
Acta Neuropathologica Communications, July 2013
DOI 10.1186/2051-5960-1-31
Pubmed ID
Authors

Lauren D Stutzbach, Sharon X Xie, Adam C Naj, Roger Albin, Sid Gilman, Virginia M Y Lee, John Q Trojanowski, Bernie Devlin, Gerard D Schellenberg

Abstract

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia, and brainstem. A genome-wide association study identified EIF2AK3 as a risk factor for PSP. EIF2AK3 encodes PERK, part of the endoplasmic reticulum's (ER) unfolded protein response (UPR). PERK is an ER membrane protein that senses unfolded protein accumulation within the ER lumen. Recently, several groups noted UPR activation in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, multiple system atrophy, and in the hippocampus and substantia nigra of PSP subjects. Here, we evaluate UPR PERK activation in the pons, medulla, midbrain, hippocampus, frontal cortex and cerebellum in subjects with PSP, AD, and in normal controls.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 191 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
Unknown 188 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 19%
Student > Bachelor 26 14%
Researcher 23 12%
Student > Master 19 10%
Professor 8 4%
Other 33 17%
Unknown 45 24%
Readers by discipline Count As %
Neuroscience 39 20%
Biochemistry, Genetics and Molecular Biology 33 17%
Agricultural and Biological Sciences 32 17%
Medicine and Dentistry 17 9%
Unspecified 8 4%
Other 12 6%
Unknown 50 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2020.
All research outputs
#2,805,269
of 22,713,403 outputs
Outputs from Acta Neuropathologica Communications
#526
of 1,366 outputs
Outputs of similar age
#24,941
of 194,293 outputs
Outputs of similar age from Acta Neuropathologica Communications
#2
of 27 outputs
Altmetric has tracked 22,713,403 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,366 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.