Title |
Is it still worthwhile to perform quarterly cd4+ t lymphocyte cell counts on hiv-1 infected stable patients?
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Published in |
BMC Infectious Diseases, February 2017
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DOI | 10.1186/s12879-017-2199-x |
Pubmed ID | |
Authors |
Antonio Di Biagio, Marta Ameri, Davide Sirello, Giovanni Cenderello, Enrico Di Bella, Lucia Taramasso, Barbara Giannini, Mauro Giacomini, Claudio Viscoli, Giovanni Cassola, Marcello Montefiori |
Abstract |
In the last 20 years routine T CD4+ lymphocyte (CD4+) cell count has proved to be a key factor to determine the stage of HIV infection and start or discontinue of prophylaxis for opportunistic infections. However, several studies recently showed that in stable patients on cART a quarterly CD4+ cell count monitoring results in limited (or null) clinical relevance. The research is intended to investigate whether performing quarterly CD4+ cell counts in stable HIV-1 patients is still recommendable and to provide a forecast of the cost saving that could be achieved by reducing CD4+ monitoring in such a category of patients. The study is based on data referring to all HIV-infected patients > 18 years of age being treated at two large infectious diseases units located in the metropolitan area of Genoa, Italy. The probability of CD4+ cell counts dropping below a threshold value set at 350 cells/mm(3) is assessed using confidence intervals and Kaplan-Meier survival estimates, whereas multivariate Cox analysis and logistic regression are implemented in order to identify factors associated with CD4+ cell count falls below 350 cells/mm(3). Statistical analysis reveals that among stable patients the probability of maintaining CD4+ >350 cell/mm(3) is more than 98%. Econometric models indicate that HCV co-infection and HIV-RNA values >50 copies/mL in previous examinations are associated with CD4+ falls below 350 cells/mm(3). Moreover, results suggest that the cost saving that could be obtained by reducing CD4+ examinations ranges from 33 to 67%. Empirical findings shows that patients defined as stable at enrollment are highly unlikely to experience a CD4+ value <350 cell/mm(3) in the space/arc of a year. The research supports a recommendation for annual CD4+ monitoring in stable HIV-1 patients. |
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United States | 2 | 25% |
Italy | 1 | 13% |
Unknown | 5 | 63% |
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Type | Count | As % |
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Members of the public | 7 | 88% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
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Switzerland | 1 | 5% |
Unknown | 21 | 95% |
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Researcher | 4 | 18% |
Other | 4 | 18% |
Student > Ph. D. Student | 3 | 14% |
Lecturer > Senior Lecturer | 2 | 9% |
Professor > Associate Professor | 1 | 5% |
Other | 0 | 0% |
Unknown | 8 | 36% |
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Computer Science | 2 | 9% |
Social Sciences | 2 | 9% |
Nursing and Health Professions | 1 | 5% |
Economics, Econometrics and Finance | 1 | 5% |
Other | 3 | 14% |
Unknown | 9 | 41% |