Title |
The FLS (Fatty liver Shionogi) mouse reveals local expressions of lipocalin-2, CXCL1 and CXCL9 in the liver with non-alcoholic steatohepatitis
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Published in |
BMC Gastroenterology, July 2013
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DOI | 10.1186/1471-230x-13-120 |
Pubmed ID | |
Authors |
Toshihisa Semba, Motoi Nishimura, Satomi Nishimura, Osamu Ohara, Takayuki Ishige, Sayaka Ohno, Ken Nonaka, Kazuyuki Sogawa, Mamoru Satoh, Setsu Sawai, Kazuyuki Matsushita, Fumio Imazeki, Osamu Yokosuka, Fumio Nomura |
Abstract |
Nonalcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of diseases, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), which carries a significant risk of progression to cirrhosis and hepatocellular carcinoma. Since NASH is a progressive but reversible condition, it is desirable to distinguish NASH from simple steatosis, and to treat NASH patients at an early stage. To establish appropriate diagnosis and therapy, the pathological mechanisms of the disease should be elucidated; however, these have not been fully clarified for both NASH and simple steatosis. This study aims to reveal the differences between simple steatosis and NASH. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 21% |
Student > Bachelor | 6 | 14% |
Student > Master | 5 | 12% |
Researcher | 5 | 12% |
Other | 3 | 7% |
Other | 5 | 12% |
Unknown | 10 | 23% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 11 | 26% |
Biochemistry, Genetics and Molecular Biology | 8 | 19% |
Medicine and Dentistry | 7 | 16% |
Immunology and Microbiology | 2 | 5% |
Chemistry | 1 | 2% |
Other | 0 | 0% |
Unknown | 14 | 33% |