Title |
Nrf2 is required to maintain the self-renewal of glioma stem cells
|
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Published in |
BMC Cancer, August 2013
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DOI | 10.1186/1471-2407-13-380 |
Pubmed ID | |
Authors |
Jianhong Zhu, Handong Wang, Qing Sun, Xiangjun Ji, Lin Zhu, Zixiang Cong, Yuan Zhou, Huandong Liu, Mengliang Zhou |
Abstract |
Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioma stem cells (GSCs). Self-renewal is a complex biological process necessary for maintaining the glioma stem cells. Nuclear factor rythroid 2-related factor 2(Nrf2) plays a significant role in protecting cells from endogenous and exogenous stresses. Nrf2 is a key nuclear transcription factor that regulates antioxidant response element (ARE)-containing genes. Previous studies have demonstrated the significant role of Nrf2 in the proliferation of glioblastoma, and in their resistance to radioactive therapies. We examined the effect of knocking down Nrf2 in GSCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
Portugal | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 68 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 17 | 24% |
Researcher | 10 | 14% |
Student > Bachelor | 7 | 10% |
Student > Doctoral Student | 6 | 8% |
Student > Master | 5 | 7% |
Other | 12 | 17% |
Unknown | 15 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 14 | 19% |
Medicine and Dentistry | 11 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Unspecified | 3 | 4% |
Other | 5 | 7% |
Unknown | 21 | 29% |