Title |
Effect of microbial siderophores on mammalian non-malignant and malignant cell lines
|
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Published in |
BMC Complementary Medicine and Therapies, March 2017
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DOI | 10.1186/s12906-017-1657-8 |
Pubmed ID | |
Authors |
Karuna Gokarn, Vishwas Sarangdhar, Ramprasad B. Pal |
Abstract |
Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment. In the present study, we have evaluated effect of three siderophores - exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay. These siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells. Based on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 33% |
Student > Ph. D. Student | 4 | 22% |
Student > Bachelor | 2 | 11% |
Other | 1 | 6% |
Researcher | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 4 | 22% |
Biochemistry, Genetics and Molecular Biology | 4 | 22% |
Chemistry | 2 | 11% |
Immunology and Microbiology | 2 | 11% |
Environmental Science | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 22% |