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Effect of microbial siderophores on mammalian non-malignant and malignant cell lines

Overview of attention for article published in BMC Complementary and Alternative Medicine, March 2017
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Citations

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Title
Effect of microbial siderophores on mammalian non-malignant and malignant cell lines
Published in
BMC Complementary and Alternative Medicine, March 2017
DOI 10.1186/s12906-017-1657-8
Pubmed ID
Authors

Karuna Gokarn, Vishwas Sarangdhar, Ramprasad B. Pal

Abstract

Iron is a vital nutrient for all cells, and malignant cells have a higher requirement for the metal due to their rapid multiplication. Bacterial siderophores can be used to reduce free ferric ion concentration from the cellular environment. In the present study, we have evaluated effect of three siderophores - exochelin-MS, mycobactin S and deferoxamine B on the proliferation of mammalian cell lines using MTT assay. These siderophores caused a significant decrease in the viability of malignant cells, without significantly affecting non-malignant cells. Based on these results, we suggest that iron-chelation therapy could be explored as an adjunctive therapeutic option against cancer along with other therapies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 38%
Professor > Associate Professor 1 13%
Student > Master 1 13%
Student > Bachelor 1 13%
Researcher 1 13%
Other 0 0%
Unknown 1 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 38%
Biochemistry, Genetics and Molecular Biology 2 25%
Immunology and Microbiology 1 13%
Unknown 2 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2017.
All research outputs
#8,963,478
of 11,218,652 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,645
of 2,351 outputs
Outputs of similar age
#189,897
of 262,768 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#36
of 51 outputs
Altmetric has tracked 11,218,652 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,351 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,768 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.