| Title |
Evaluation of muscle strength and motor abilities in children with type II and III spinal muscle atrophy treated with valproic acid
|
|---|---|
| Published in |
BMC Neurology, March 2011
|
| DOI | 10.1186/1471-2377-11-36 |
| Pubmed ID | |
| Authors |
Illora A Darbar, Paulo G Plaggert, Maria Bernadete D Resende, Edmar Zanoteli, Umbertina C Reed |
| Abstract |
Spinal muscular atrophy (SMA) is an autosomal recessive disorder that affects the motoneurons of the spinal anterior horn, resulting in hypotonia and muscle weakness. The disease is caused by deletion or mutation in the telomeric copy of SMN gene (SMN1) and clinical severity is in part determined by the copy number of the centromeric copy of the SMN gene (SMN2). The SMN2 mRNA lacks exon 7, resulting in a production of lower amounts of the full-length SMN protein. Knowledge of the molecular mechanism of diseases has led to the discovery of drugs capable of increasing SMN protein level through activation of SMN2 gene. One of these drugs is the valproic acid (VPA), a histone deacetylase inhibitor. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 3% |
| Spain | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 101 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 16% |
| Student > Master | 15 | 14% |
| Student > Ph. D. Student | 10 | 9% |
| Student > Postgraduate | 8 | 8% |
| Student > Doctoral Student | 8 | 8% |
| Other | 15 | 14% |
| Unknown | 33 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 20% |
| Nursing and Health Professions | 13 | 12% |
| Agricultural and Biological Sciences | 9 | 8% |
| Neuroscience | 7 | 7% |
| Sports and Recreations | 6 | 6% |
| Other | 14 | 13% |
| Unknown | 36 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2023.
All research outputs
#5,089,897
of 25,253,876 outputs
Outputs from BMC Neurology
#664
of 2,680 outputs
Outputs of similar age
#23,815
of 114,519 outputs
Outputs of similar age from BMC Neurology
#8
of 14 outputs
Altmetric has tracked 25,253,876 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,680 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,519 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.