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Evaluation of muscle strength and motor abilities in children with type II and III spinal muscle atrophy treated with valproic acid

Overview of attention for article published in BMC Neurology, March 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

twitter
1 tweeter
wikipedia
2 Wikipedia pages

Citations

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25 Dimensions

Readers on

mendeley
56 Mendeley
Title
Evaluation of muscle strength and motor abilities in children with type II and III spinal muscle atrophy treated with valproic acid
Published in
BMC Neurology, March 2011
DOI 10.1186/1471-2377-11-36
Pubmed ID
Authors

Illora A Darbar, Paulo G Plaggert, Maria Bernadete D Resende, Edmar Zanoteli, Umbertina C Reed

Abstract

Spinal muscular atrophy (SMA) is an autosomal recessive disorder that affects the motoneurons of the spinal anterior horn, resulting in hypotonia and muscle weakness. The disease is caused by deletion or mutation in the telomeric copy of SMN gene (SMN1) and clinical severity is in part determined by the copy number of the centromeric copy of the SMN gene (SMN2). The SMN2 mRNA lacks exon 7, resulting in a production of lower amounts of the full-length SMN protein. Knowledge of the molecular mechanism of diseases has led to the discovery of drugs capable of increasing SMN protein level through activation of SMN2 gene. One of these drugs is the valproic acid (VPA), a histone deacetylase inhibitor.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 5%
Croatia 1 2%
Germany 1 2%
Spain 1 2%
Unknown 50 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 27%
Student > Master 10 18%
Unspecified 8 14%
Student > Ph. D. Student 6 11%
Student > Doctoral Student 5 9%
Other 12 21%
Readers by discipline Count As %
Medicine and Dentistry 17 30%
Agricultural and Biological Sciences 10 18%
Unspecified 10 18%
Sports and Recreations 5 9%
Neuroscience 4 7%
Other 10 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2018.
All research outputs
#3,442,233
of 12,931,128 outputs
Outputs from BMC Neurology
#398
of 1,456 outputs
Outputs of similar age
#62,062
of 250,367 outputs
Outputs of similar age from BMC Neurology
#49
of 199 outputs
Altmetric has tracked 12,931,128 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,456 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,367 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 199 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.