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Immunological and virological characterization of HIV-1 viremia controllers in the North Region of Brazil

Overview of attention for article published in BMC Infectious Diseases, June 2017
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Title
Immunological and virological characterization of HIV-1 viremia controllers in the North Region of Brazil
Published in
BMC Infectious Diseases, June 2017
DOI 10.1186/s12879-017-2491-9
Pubmed ID
Authors

Samara Tatielle M. Gomes, Érica R. Gomes, Mike B. dos Santos, Sandra S. Lima, Maria Alice F. Queiroz, Luiz Fernando A. Machado, Izaura M. V. Cayres-Vallinoto, Antonio Carlos R. Vallinoto, Marluísa de O. Guimarães Ishak, Ricardo Ishak

Abstract

A rare phenotype of clinical non-progressors to AIDS is not well understood and the new protocol for universal treatment, may block the understanding of viral control thus it is crucial to define this controversial group. A cohort of 30 persons followed a criteria for viremia control groups 1 (VC1; n = 2) and 2 (VC2; n = 7) and non-viral controllers (NC; n = 21) including number of years of diagnosis, LTCD4(+), LTCD8(+) counts, plasma viral load and the absence of ART; 241 uninfected control persons were matched to age and sex. Infected persons were regularly examined and submitted to two or three annual laboratory measurements. Polymorphisms and allele frequencies of CCR5Δ32 and SDF1-3'A were detected in the genomic DNA. Plasma levels of cytokines (IL-2, IL-4, IL-5, IL-9, IL-10, IL-13, IL-17 and IFN-y) were measured. The group investigated is originated from a miscigenetic population and demographic and social characteristics were not significantly relevant. LTCD4(+) median values were higher among VC than NC, but significantly lower than uninfected controls. Evolution of LTCD4(+) and LTCD8(+) counts, showed a slight increase of LTCD4(+) among VC, but a significant decrease in the NC. The percentage of annual change in LTCD4(+) was also significantly different between the groups. LTCD4(+)/LTCD8(+) ratio was inverted but not significant among the VC, thus the ratio may be a useful biomarker for the VC. A clear signature indicated a change from Th1 to Th2 cytokine profiles from VC to NC, respectively. The knowledge of viral controllers characteristics in different population groups is important to define a strict universal definition for the sake of learning about the pathogenesis of HIV-1. Data on LTCD4(+) seems to be stable and repetitive from published data, but the LTCD8(+) response and the significance of LTCD4(+)/LTCD8(+) ratio values are in need to further exploration as biomarkers. The change from Th1 to Th2 cytokine profile may help to design and adjust specific treatment protocols for the group.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 36%
Unspecified 4 29%
Student > Master 2 14%
Student > Postgraduate 1 7%
Professor > Associate Professor 1 7%
Other 1 7%
Readers by discipline Count As %
Unspecified 6 43%
Immunology and Microbiology 4 29%
Agricultural and Biological Sciences 2 14%
Biochemistry, Genetics and Molecular Biology 1 7%
Social Sciences 1 7%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2017.
All research outputs
#6,832,257
of 11,419,765 outputs
Outputs from BMC Infectious Diseases
#2,151
of 4,243 outputs
Outputs of similar age
#139,277
of 268,058 outputs
Outputs of similar age from BMC Infectious Diseases
#46
of 105 outputs
Altmetric has tracked 11,419,765 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,243 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,058 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.