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Inhalation of carbon monoxide is ineffective as a long-term therapy to reduce obesity in mice fed a high fat diet

Overview of attention for article published in BMC Obesity, March 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#40 of 162)
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
8 tweeters
facebook
1 Facebook page

Citations

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1 Dimensions

Readers on

mendeley
9 Mendeley
Title
Inhalation of carbon monoxide is ineffective as a long-term therapy to reduce obesity in mice fed a high fat diet
Published in
BMC Obesity, March 2014
DOI 10.1186/2052-9538-1-6
Pubmed ID
Authors

Peter A Hosick, Elhaitham K Ahmed, Monette U Gousset, Joey P Granger, David E Stec

Abstract

Previous studies have demonstrated that induction of heme oxygenase-1 results in weight loss in several rodent models of obesity. However, the specific role of the heme oxygenase-1 metabolite, carbon monoxide (CO), in this response has yet to be established. We recently reported that chronic treatment with CO releasing molecules results in prevention of weight gain in mice fed a high fat diet. In the present study, we sought to determine the effect of chronic CO inhalation on the development and reversal of high fat diet induced obesity. CO inhalation at both levels initially resulted in a prevention and reversal of body weight and fat mass over the first 10 weeks of treatment, however, this effect was not sustained. CO inhalation in the prevention groups also had an early effect to lower fasting blood glucose but this effect also was not sustained. Our results demonstrate that CO inhalation has a transient effect to prevent and reduce body weight which is not sustained chronically in mice fed a high fat diet. These results suggest that chronic CO inhalation therapy is not an effective treatment to induce long term weight loss.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 4 44%
Student > Bachelor 2 22%
Student > Master 1 11%
Student > Doctoral Student 1 11%
Student > Ph. D. Student 1 11%
Other 0 0%
Readers by discipline Count As %
Unspecified 5 56%
Biochemistry, Genetics and Molecular Biology 2 22%
Agricultural and Biological Sciences 2 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2014.
All research outputs
#1,781,729
of 12,301,875 outputs
Outputs from BMC Obesity
#40
of 162 outputs
Outputs of similar age
#30,954
of 195,258 outputs
Outputs of similar age from BMC Obesity
#2
of 5 outputs
Altmetric has tracked 12,301,875 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 162 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,258 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.