| Title |
Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system
|
|---|---|
| Published in |
BMC Biology, April 2008
|
| DOI | 10.1186/jbiol69 |
| Pubmed ID | |
| Authors |
Ruolan Han, Yin M Yang, Joerg Dietrich, Anne Luebke, Margot Mayer-Pröschel, Mark Noble |
| Abstract |
Cancer treatment with a variety of chemotherapeutic agents often is associated with delayed adverse neurological consequences. Despite their clinical importance, almost nothing is known about the basis for such effects. It is not even known whether the occurrence of delayed adverse effects requires exposure to multiple chemotherapeutic agents, the presence of both chemotherapeutic agents and the body's own response to cancer, prolonged damage to the blood-brain barrier, inflammation or other such changes. Nor are there any animal models that could enable the study of this important problem. |
Mendeley readers
The data shown below were compiled from readership statistics for 195 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 190 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 21% |
| Student > Bachelor | 27 | 14% |
| Student > Master | 26 | 13% |
| Researcher | 21 | 11% |
| Student > Doctoral Student | 11 | 6% |
| Other | 37 | 19% |
| Unknown | 32 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 40 | 21% |
| Medicine and Dentistry | 34 | 17% |
| Neuroscience | 24 | 12% |
| Biochemistry, Genetics and Molecular Biology | 16 | 8% |
| Psychology | 13 | 7% |
| Other | 33 | 17% |
| Unknown | 35 | 18% |