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The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice

Overview of attention for article published in BMC Musculoskeletal Disorders, August 2011
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 tweeter
facebook
1 Facebook page

Citations

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39 Dimensions

Readers on

mendeley
54 Mendeley
Title
The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice
Published in
BMC Musculoskeletal Disorders, August 2011
DOI 10.1186/1471-2474-12-185
Pubmed ID
Authors

Annabelle Z Caron, Sonia Haroun, Élisabeth Leblanc, Frédéric Trensz, Chantal Guindi, Aziz Amrani, Guillaume Grenier

Abstract

Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction. This debilitating condition is associated with a marked activation of NFκB activity. The ubiquitin-proteasome pathway degrades the NFκB inhibitor IκBα, enabling NFκB to translocate to the nucleus and bind to the target genes that promote muscle atrophy. Although several studies showed that proteasome inhibitors are efficient to reduce atrophy, no studies have demonstrated the ability of these inhibitors to preserve muscle function under catabolic condition.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 2%
United States 1 2%
Unknown 52 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 26%
Researcher 10 19%
Professor > Associate Professor 6 11%
Student > Master 6 11%
Unspecified 5 9%
Other 12 22%
Unknown 1 2%
Readers by discipline Count As %
Agricultural and Biological Sciences 22 41%
Medicine and Dentistry 11 20%
Biochemistry, Genetics and Molecular Biology 9 17%
Unspecified 6 11%
Sports and Recreations 3 6%
Other 2 4%
Unknown 1 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2011.
All research outputs
#1,811,141
of 3,627,074 outputs
Outputs from BMC Musculoskeletal Disorders
#724
of 1,374 outputs
Outputs of similar age
#20,766
of 55,810 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#24
of 43 outputs
Altmetric has tracked 3,627,074 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,374 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 55,810 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.