Title |
Malignant melanoma arising from a perianal fistula and harbouring a BRAFgene mutation: a case report
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Published in |
BMC Cancer, August 2011
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DOI | 10.1186/1471-2407-11-343 |
Pubmed ID | |
Authors |
Conrado Martinez-Cadenas, Nuria Bosch, Lucas Peñas, Esther Flores-Couce, Enrique Ochoa, Javier Munárriz, Juan P Aracil, Marcos Tajahuerce, Ramón Royo, Rafael Lozoya, Enrique Boldó |
Abstract |
Melanoma of the anal region is a very uncommon disease, accounting for only 0.2-0.3% of all melanoma cases. Mutations of the BRAF gene are usually absent in melanomas occurring in this region as well as in other sun-protected regions. The development of a tumour in a longstanding perianal fistula is also extremely rare. More frequent is the case of a tumour presenting as a fistula, that is, the fistula being a consequence of the cancerous process, although we have found only two cases of fistula-generating melanomas reported in the literature. |
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