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Dark matter RNA illuminates the puzzle of genome-wide association studies

Overview of attention for article published in BMC Medicine, June 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
2 blogs
twitter
15 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
23 Dimensions

Readers on

mendeley
41 Mendeley
Title
Dark matter RNA illuminates the puzzle of genome-wide association studies
Published in
BMC Medicine, June 2014
DOI 10.1186/1741-7015-12-97
Pubmed ID
Authors

Georges St. Laurent, Yuri Vyatkin, Philipp Kapranov

Abstract

In the past decade, numerous studies have made connections between sequence variants in human genomes and predisposition to complex diseases. However, most of these variants lie outside of the charted regions of the human genome whose function we understand; that is, the sequences that encode proteins. Consequently, the general concept of a mechanism that translates these variants into predisposition to diseases has been lacking, potentially calling into question the validity of these studies. Here we make a connection between the growing class of apparently functional RNAs that do not encode proteins and whose function we do not yet understand (the so-called 'dark matter' RNAs) and the disease-associated variants. We review advances made in a different genomic mapping effort - unbiased profiling of all RNA transcribed from the human genome - and provide arguments that the disease-associated variants exert their effects via perturbation of regulatory properties of non-coding RNAs existing in mammalian cells.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Norway 1 2%
Netherlands 1 2%
Canada 1 2%
Unknown 37 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 29%
Student > Ph. D. Student 7 17%
Student > Doctoral Student 4 10%
Professor 4 10%
Student > Master 4 10%
Other 10 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 51%
Biochemistry, Genetics and Molecular Biology 9 22%
Unspecified 4 10%
Medicine and Dentistry 4 10%
Economics, Econometrics and Finance 1 2%
Other 2 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2015.
All research outputs
#657,463
of 13,316,521 outputs
Outputs from BMC Medicine
#565
of 2,121 outputs
Outputs of similar age
#11,274
of 189,864 outputs
Outputs of similar age from BMC Medicine
#1
of 5 outputs
Altmetric has tracked 13,316,521 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,121 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.9. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,864 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them