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Astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression

Overview of attention for article published in BMC Complementary and Alternative Medicine, October 2014
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1 tweeter

Citations

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Readers on

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20 Mendeley
Title
Astragalus saponins modulates colon cancer development by regulating calpain-mediated glucose-regulated protein expression
Published in
BMC Complementary and Alternative Medicine, October 2014
DOI 10.1186/1472-6882-14-401
Pubmed ID
Authors

Yue Wang, Kathy K Auyeung, Xiaoyu Zhang, Joshua K Ko

Abstract

Glucose-regulated proteins (GRP) are induced in the cancer microenvironment to promote tumor survival, metastasis and drug resistance. AST was obtained from the medicinal plant Astragalus membranaceus, which possesses anti-tumor and pro-apoptotic properties in colon cancer cells and tumor xenograft. The present study aimed to investigate the involvement of GRP in endoplasmic reticulum (ER) stress-mediated apoptosis during colon cancer development, with focus on the correlation between AST-evoked regulation of GRP and calpain activation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 20%
Student > Ph. D. Student 4 20%
Unspecified 3 15%
Other 2 10%
Student > Bachelor 2 10%
Other 5 25%
Readers by discipline Count As %
Medicine and Dentistry 5 25%
Agricultural and Biological Sciences 5 25%
Biochemistry, Genetics and Molecular Biology 4 20%
Business, Management and Accounting 2 10%
Unspecified 2 10%
Other 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2014.
All research outputs
#4,191,538
of 5,038,401 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,359
of 1,550 outputs
Outputs of similar age
#113,543
of 142,137 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#85
of 102 outputs
Altmetric has tracked 5,038,401 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,550 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 142,137 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.