| Title |
Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence
|
|---|---|
| Published in |
BMC Cancer, October 2014
|
| DOI | 10.1186/1471-2407-14-775 |
| Pubmed ID | |
| Authors |
Jaspreet Kaur Dhanjal, Nupur Nigam, Sudhanshu Sharma, Anupama Chaudhary, Sunil C Kaul, Abhinav Grover, Renu Wadhwa |
| Abstract |
Embelin, a quinone derivative, is found in the fruits of Embelia ribes Burm (Myrsinaceae). It has been shown to have a variety of therapeutic potentials including anthelmintic, anti-tumor, anti-diabetic, anti-bacterial and anti-inflammation. Inflammation is an immunological response to external harmful stimuli and is regulated by an endogenous pyrogen and pleiotropic pro-inflammatory cytokine, tumor necrosis factor alpha (TNF-α). TNF-α production has been implicated in a variety of other human pathologies including neurodegeneration and cancer. Several studies have shown that the anti-inflammatory activity of embelin is mediated by reduction in TNF-α. The latter is synthesized as a membrane anchored protein (pro-TNF-α); the soluble component of pro-TNF-α is then released into the extracellular space by the action of a protease called TNF-α converting enzyme (TACE). TACE, hence, has been proposed as a therapeutic target for inflammation and cancer. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
| Scientists | 1 | 33% |
| Unknown | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 27% |
| Researcher | 8 | 16% |
| Student > Master | 6 | 12% |
| Other | 3 | 6% |
| Student > Bachelor | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 13 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 16% |
| Agricultural and Biological Sciences | 7 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
| Medicine and Dentistry | 5 | 10% |
| Chemistry | 4 | 8% |
| Other | 9 | 18% |
| Unknown | 13 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2014.
All research outputs
#14,788,263
of 22,768,097 outputs
Outputs from BMC Cancer
#3,661
of 8,278 outputs
Outputs of similar age
#143,845
of 260,345 outputs
Outputs of similar age from BMC Cancer
#82
of 177 outputs
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So far Altmetric has tracked 8,278 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 50% of its peers.
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We're also able to compare this research output to 177 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.