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Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study

Overview of attention for article published in BMC Pregnancy and Childbirth, December 2014
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Title
Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study
Published in
BMC Pregnancy and Childbirth, December 2014
DOI 10.1186/s12884-014-0395-x
Pubmed ID
Authors

Gergely Fügedi, Miklós Molnár, János Rigó, Júlia Schönléber, Ilona Kovalszky, Attila Molvarec

Abstract

BackgroundThe endocannabinoid system plays a key role in female reproduction, including implantation, decidualization and placentation. In the present study, we aimed to analyze cannabinoid receptor 1 (CB1), CB2 and fatty acid amid hydrolase (FAAH) expressions and localization in normal and preeclamptic placenta, in order to determine whether placental endocannabinoid expression pattern differs between normal pregnancy and preeclampsia.MethodsEighteen preeclamptic patients and 18 normotensive, healthy pregnant women with uncomplicated pregnancies were involved in our case¿control study. We determined CB1, CB2 and FAAH expressions by Western blotting and immunohistochemistry in placental samples collected directly after Cesarean section.ResultsCB1 expression semi-quantified by Western blotting was significantly higher in preeclamptic placenta, and these findings were confirmed by immunohistochemistry. CB1 immunoreactivity was markedly stronger in syncytiotrophoblasts, the mesenchymal core, decidua, villous capillary endothelial and smooth muscle cells, as well as in the amnion in preeclamptic samples compared to normal pregnancies. However, we did not find significant differences between preeclamptic and normal placenta in terms of CB2 and FAAH expressions and immunoreactivity.ConclusionsWe observed markedly higher expression of CB1 protein in preeclamptic placental tissue. Increased CB1 expression might cause abnormal decidualization and impair trophoblast invasion, thus being involved in the pathogenesis of preeclampsia. Nevertheless, we did not find significant differences between preeclamptic and normal placental tissue regarding CB2 and FAAH expressions. While the detailed pathogenesis of preeclampsia is still unclear, the endocannabinoid system could play a role in the development of the disease.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 6%
United States 1 6%
Unknown 16 89%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 22%
Unspecified 4 22%
Student > Ph. D. Student 3 17%
Student > Postgraduate 2 11%
Researcher 2 11%
Other 3 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 22%
Unspecified 4 22%
Agricultural and Biological Sciences 4 22%
Medicine and Dentistry 3 17%
Nursing and Health Professions 2 11%
Other 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2014.
All research outputs
#2,963,218
of 4,580,192 outputs
Outputs from BMC Pregnancy and Childbirth
#883
of 1,140 outputs
Outputs of similar age
#92,230
of 147,349 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#39
of 55 outputs
Altmetric has tracked 4,580,192 research outputs across all sources so far. This one is in the 31st percentile – i.e., 31% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,140 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.