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Hepatitis C virus eradication improves immediate and delayed episodic memory in patients treated with interferon and ribavirin

Overview of attention for article published in BMC Gastroenterology, November 2017
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Title
Hepatitis C virus eradication improves immediate and delayed episodic memory in patients treated with interferon and ribavirin
Published in
BMC Gastroenterology, November 2017
DOI 10.1186/s12876-017-0679-5
Pubmed ID
Authors

Mary Ellen Dias Barbosa, Ana Luiza Zaninotto, Daniel Ferraz de Campos Mazo, Mario Guimarães Pessoa, Cláudia Pinto Marques Souza de Oliveira, Flair José Carrilho, Alberto Queiroz Farias

Abstract

Chronic hepatitis C virus (HCV) infection is associated with impairment of cognitive function and mood disorders. Our aim was to evaluate the impact of sustained virological response (SVR) on cognitive function and mood disorders. A prospective exploratory one arm study was conducted. Adult clinically compensated HVC patients were consecutively recruited before treatment with interferon and ribavirin for 24 to 48 weeks, according to HCV genotype. Clinical, neurocognitive and mood assessments using the PRIME-MD and BDI instruments were performed at baseline, right after half of the expected treatment has been reached and 6 months after the end of antiviral treatment. Exclusion criteria were the use of illicit psychotropic substances, mental confusion, hepatic encephalopathy, hepatocellular carcinoma, severe anemia, untreated hypothyroidism, Addison syndrome and major depression before treatment. Thirty six patients were enrolled and 21 completed HCV treatment (n = 16 with SVR and n = 5 without). Regardless of the viral clearance at the end of treatment, there was a significant improvement in the immediate verbal episodic memory (p = 0.010), delayed verbal episodic memory (p = 0.007), selective attention (p < 0.001) and phonemic fluency (p = 0.043). Patients with SVR displayed significant improvement in immediate (p = 0.045) and delayed verbal episodic memory (p = 0.040) compared to baseline. The baseline frequency of depression was 9.5%, which rose to 52.4% during treatment, and returned to 9.5% 6 months after the end of treatment, without significant difference between patients with and without SVR. Depressive symptoms were observed in 19.1% before treatment, 62% during (p = 0.016) and 28.6% 6 months after the end of treatment (p = 0.719). Eradication of HCV infection improved cognitive performance but did not affect the frequency of depressive symptoms at least in the short range.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 25%
Unspecified 8 25%
Researcher 6 19%
Student > Master 5 16%
Student > Doctoral Student 2 6%
Other 3 9%
Readers by discipline Count As %
Unspecified 10 31%
Psychology 9 28%
Medicine and Dentistry 7 22%
Neuroscience 3 9%
Computer Science 1 3%
Other 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2017.
All research outputs
#10,826,259
of 12,211,623 outputs
Outputs from BMC Gastroenterology
#660
of 791 outputs
Outputs of similar age
#281,694
of 338,971 outputs
Outputs of similar age from BMC Gastroenterology
#29
of 50 outputs
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