| Title |
Effects of mistletoe products on pharmacokinetic drug turnover by inhibition and induction of cytochrome P450 activities
|
|---|---|
| Published in |
BMC Complementary Medicine and Therapies, December 2017
|
| DOI | 10.1186/s12906-017-2028-1 |
| Pubmed ID | |
| Authors |
Michael Schink, Oliver Dehus |
| Abstract |
European mistletoe (Viscum album) products used in cancer therapy are frequently combined with other anti-cancer-drugs. Hence, potential herb-drug interactions have become a major safety concern in mistletoe therapy. Three European mistletoe products (Helixor® A, Helixor® M and Helixor® P from mistletoe grown on firs, apple trees and pines, respectively) were tested for inhibition of nine major cytochrome P450 (CYP) isoenzymes in a test system using pooled human liver microsomes and for induction of five CYP isoforms in human hepatocytes cultivated in vitro according to the relevant guideline. Major inhibition did not occur in any of the CYP marker reactions. For some CYP isoenzymes, a minor or intermediate inhibition could be observed, but without dose effect relationship. Induction activity (≥ 1.5-fold increase) was not found with any of the three mistletoe products. Since no induction capacity was found and major inhibition above 50% did not occur even with the highest concentration used, which is approximately 100,000-fold higher than the clinically relevant dose in plasma, a clinically relevant herb-drug interaction is not expected for Helixor® A, M, and P. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| United Kingdom | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 33% |
| Scientists | 1 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 2 | 15% |
| Student > Master | 2 | 15% |
| Researcher | 2 | 15% |
| Student > Bachelor | 1 | 8% |
| Student > Doctoral Student | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 4 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 23% |
| Biochemistry, Genetics and Molecular Biology | 3 | 23% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
| Nursing and Health Professions | 1 | 8% |
| Business, Management and Accounting | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 4 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2022.
All research outputs
#15,879,351
of 24,195,945 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,884
of 3,798 outputs
Outputs of similar age
#260,964
of 447,390 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#39
of 85 outputs
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So far Altmetric has tracked 3,798 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
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