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Predictors and outcomes of Mycobacterium tuberculosis bacteremia among patients with HIV and tuberculosis co-infection enrolled in the ACTG A5221 STRIDE study

Overview of attention for article published in BMC Infectious Diseases, January 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)

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51 Mendeley
Title
Predictors and outcomes of Mycobacterium tuberculosis bacteremia among patients with HIV and tuberculosis co-infection enrolled in the ACTG A5221 STRIDE study
Published in
BMC Infectious Diseases, January 2015
DOI 10.1186/s12879-014-0735-5
Pubmed ID
Authors

John A Crump, Xingye Wu, Michelle A Kendall, Prudence D Ive, Johnstone J Kumwenda, Beatriz Grinsztejn, Ute Jentsch, Susan Swindells

Abstract

BackgroundTo evaluate predictors and outcomes of Mycobacterium tuberculosis bacteremia among participants undergoing baseline mycobacterial blood culture in the ACTG A5221 STRIDE study, a randomized clinical trial comparing earlier with later ART among HIV-infected patients suspected of having tuberculosis with CD4-positive T-lymphocyte counts (CD4 counts) <250 cells/mm3. We conducted a secondary analysis comparing participants with respect to presence or absence of M. tuberculosis bacteremia.MethodsParticipants with a baseline mycobacterial blood culture were compared with respect to the presence or absence of M. tuberculosis bacteremia. Baseline predictors of M. tuberculosis bacteremia were identified and participant outcomes were compared by mycobacteremia status.ResultsOf 90 participants with baseline mycobacterial blood cultures, 29 (32.2%) were female, the median (IQR) age was 37 (31¿45) years, CD4 count was 81 (33¿131) cells/mm3, HIV-1 RNA level was 5.39 (4.96¿5.83) log10 copies/mL, and 18 (20.0%) were positive for M. tuberculosis. In multivariable analysis, lower CD4 count (OR 0.85 per 10-cell increase, p¿=¿0.012), hemoglobin ¿8.5 g/dL (OR 5.8, p¿=¿0.049), and confirmed tuberculosis (OR 17.4, p¿=¿0.001) were associated with M. tuberculosis bacteremia. There were no significant differences in survival and AIDS-free survival, occurrence of tuberculosis IRIS, or treatment interruption or discontinuation by M. tuberculosis bacteremia status. IRIS did not differ significantly between groups despite trends toward more virologic suppression and greater CD4 count increases at week 48 in the bacteremic group.ConclusionsAmong HIV-infected tuberculosis suspects, lower CD4 count, hemoglobin ¿8.5 g/dL, and the presence of microbiologically confirmed pulmonary tuberculosis were associated with increased adjusted odds of mycobacteremia. No evidence of an association between M. tuberculosis bacteremia and the increased risk of IRIS was detected.Trial registrationClinicalTrials.gov: NCT00108862.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ethiopia 1 2%
Brazil 1 2%
Unknown 49 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 25%
Researcher 12 24%
Student > Ph. D. Student 8 16%
Unspecified 5 10%
Student > Postgraduate 3 6%
Other 10 20%
Readers by discipline Count As %
Medicine and Dentistry 17 33%
Unspecified 10 20%
Nursing and Health Professions 8 16%
Social Sciences 5 10%
Biochemistry, Genetics and Molecular Biology 3 6%
Other 8 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2019.
All research outputs
#7,530,978
of 13,384,384 outputs
Outputs from BMC Infectious Diseases
#2,104
of 4,984 outputs
Outputs of similar age
#113,597
of 277,478 outputs
Outputs of similar age from BMC Infectious Diseases
#3
of 4 outputs
Altmetric has tracked 13,384,384 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,984 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 55% of its peers.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.