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Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy)

Overview of attention for article published in BMC Ophthalmology, March 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#17 of 483)
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

news
1 news outlet
twitter
3 tweeters

Citations

dimensions_citation
11 Dimensions

Readers on

mendeley
29 Mendeley
Title
Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy)
Published in
BMC Ophthalmology, March 2015
DOI 10.1186/s12886-015-0008-0
Pubmed ID
Authors

Felix Grassmann, Richard Bergholz, Julia Mändl, Herbert Jägle, Klaus Ruether, Bernhard HF Weber

Abstract

Chloroquine (CQ) and hydroxychloroquine (HCQ) are used to treat auto-immune related diseases such as rheumatoid arthritis (RA) or systemic lupus erythematosus. Both drugs however can cause retinal toxicity eventually leading to irreversible maculopathy and retinopathy. Established risk factors are duration and dosage of treatment while the involvement of genetic factors contributing to toxic maculopathy is largely unclear. To address the latter issue, this study aimed to expand on earlier efforts by (1) evaluating risk-altering variants known to be associated with age-related macular degeneration (AMD), a frequent maculopathy in individuals over 55 years of age, and (2) determining the contribution of genetic variants in the coding sequence of the ABCA4 gene.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 7%
United States 1 3%
Unknown 26 90%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 24%
Researcher 6 21%
Unspecified 4 14%
Student > Doctoral Student 3 10%
Other 3 10%
Other 5 17%
Unknown 1 3%
Readers by discipline Count As %
Medicine and Dentistry 14 48%
Biochemistry, Genetics and Molecular Biology 4 14%
Unspecified 3 10%
Agricultural and Biological Sciences 2 7%
Computer Science 1 3%
Other 4 14%
Unknown 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2015.
All research outputs
#606,937
of 7,188,283 outputs
Outputs from BMC Ophthalmology
#17
of 483 outputs
Outputs of similar age
#24,910
of 197,842 outputs
Outputs of similar age from BMC Ophthalmology
#5
of 28 outputs
Altmetric has tracked 7,188,283 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 483 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 197,842 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.