Title |
Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients
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Published in |
BMC Musculoskeletal Disorders, March 2015
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DOI | 10.1186/s12891-015-0516-3 |
Pubmed ID | |
Authors |
Alicia Santos Savio, Ana Cecilia Machado Diaz, Araceli Chico Capote, Jamilet Miranda Navarro, Yunier Rodríguez Alvarez, Ricardo Bringas Pérez, Miguel Estévez del Toro, Gerardo E Guillen Nieto |
Abstract |
Pro-inflammatory cytokines are directly implicated in the pathogenesis of Rheumatoid arthritis (RA). Variable clinical response to cytokine targeted therapies as TNFalpha and IL-6, strongly highlights the heterogeneity of inflammatory process in RA. Another cytokine, IL-15 has also been related to the inflammatory process in RA. Recently we described for the first time, the presence of its specific receptor, IL-15Ralpha, in synovial fluid (SF). The aim of this work was to compare the expression profile of IL-15Ralpha, its ligand IL-15, TNFalpha and IL-6 and how these cytokines are correlated in SF from RA patients taking as a reference Osteoarthritis (OA), an articular but not autoinmmune disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 2% |
Unknown | 60 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 7 | 11% |
Student > Master | 6 | 10% |
Student > Postgraduate | 6 | 10% |
Researcher | 6 | 10% |
Student > Ph. D. Student | 6 | 10% |
Other | 12 | 20% |
Unknown | 18 | 30% |
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Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 12 | 20% |
Unknown | 16 | 26% |