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Gender-specific mortality in DTP-IPV- and MMR ± MenC-eligible age groups to determine possible sex-differential effects of vaccination: an observational study

Overview of attention for article published in BMC Infectious Diseases, March 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

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Title
Gender-specific mortality in DTP-IPV- and MMR ± MenC-eligible age groups to determine possible sex-differential effects of vaccination: an observational study
Published in
BMC Infectious Diseases, March 2015
DOI 10.1186/s12879-015-0898-8
Pubmed ID
Authors

Tessa M Schurink-van’t Klooster, Mirjam J Knol, Hester E de Melker, Marianne AB van der Sande

Abstract

Several studies suggested that vaccines could have non-specific effects on mortality depending on the type of vaccine. Non-specific effects seem to be different in boys and girls. In this study we want to investigate whether there are differences in gender-specific mortality among Dutch children according to the last vaccination received. We tested the hypothesis that the mortality rate ratio for girls versus boys is more favourable for girls following MMR ± MenC vaccination (from 14 months of age) compared with the ratio following DTP-IPV vaccination (2-13 months of age). Secondarily, we investigated whether there were gender-specific changes in mortality following booster vaccination at 4 years of age. This observational study included all Dutch children aged 0-11 years from 2000 until 2011. Age groups were classified according to the last vaccination offered. The mortality rates for all natural causes of death were calculated by gender and age group. Incidence rate ratios (IRRs) were computed using a multivariable Poisson analysis to compare mortality in boys and girls across different age groups. The study population consisted of 6,261,472 children. During the study period, 14,038 children (0.22%) died, 91% of which were attributed to a known natural cause of death. The mortality rate for natural causes was higher among boys than girls in all age groups. Adjusted IRRs for girls compared with boys ranged between 0.81 (95% CI 0.74-0.89) and 0.91 (95% CI 0.77-1.07) over the age groups. The IRR did not significantly differ between all vaccine-related age groups (p = 0.723), between children 2-13 months (following DTP-IPV vaccination) and 14 months - 3 years (following MMR ± MenC vaccination) (p = 0.493) and between children 14 months - 3 years and 4-8 years old (following DTP-IPV vaccination) (p = 0.868). In the Netherlands, a high income country, no differences in gender-specific mortality related to the type of last vaccination received were observed in DTP-IPV- and MMR ± MenC eligible age groups. The inability to detect this effect indicates that when non-specific effects were present the effects were not reflected in changes in the differences in mortality between boys and girls. The findings in this large population-based study are reassuring for the continued trust in the safety of the national vaccination programme.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 18%
Student > Bachelor 4 12%
Student > Ph. D. Student 4 12%
Student > Doctoral Student 3 9%
Other 2 6%
Other 7 21%
Unknown 8 24%
Readers by discipline Count As %
Medicine and Dentistry 14 41%
Nursing and Health Professions 6 18%
Veterinary Science and Veterinary Medicine 1 3%
Mathematics 1 3%
Unspecified 1 3%
Other 2 6%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2018.
All research outputs
#6,951,616
of 22,796,179 outputs
Outputs from BMC Infectious Diseases
#2,239
of 7,674 outputs
Outputs of similar age
#81,827
of 263,362 outputs
Outputs of similar age from BMC Infectious Diseases
#30
of 148 outputs
Altmetric has tracked 22,796,179 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 7,674 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,362 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 148 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.