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Comparison of cytotoxicity and genotoxicity of 4-hydroxytamoxifen in combination with Tualang honey in MCF-7 and MCF-10A cells

Overview of attention for article published in BMC Complementary and Alternative Medicine, March 2014
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1 tweeter

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39 Mendeley
Title
Comparison of cytotoxicity and genotoxicity of 4-hydroxytamoxifen in combination with Tualang honey in MCF-7 and MCF-10A cells
Published in
BMC Complementary and Alternative Medicine, March 2014
DOI 10.1186/1472-6882-14-106
Pubmed ID
Authors

Nik Soriani Yaacob, Nur Faezah Ismail

Abstract

The Malaysian Tualang honey (TH) is not only cytotoxic to human breast cancer cell lines but it has recently been reported to promote the anticancer activity induced by tamoxifen in MCF-7 and MDA-MB-231 cells suggesting its potential as an adjuvant for the chemotherapeutic agent. However, tamoxifen produces adverse effects that could be due to its ability to induce cellular DNA damage. Therefore, the study is undertaken to determine the possible modulation of the activity of 4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, by TH in non-cancerous epithelial cell line, MCF-10A, in comparison with MCF-7 cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 7 18%
Student > Bachelor 7 18%
Student > Ph. D. Student 6 15%
Student > Master 6 15%
Student > Postgraduate 3 8%
Other 9 23%
Unknown 1 3%
Readers by discipline Count As %
Unspecified 9 23%
Medicine and Dentistry 7 18%
Biochemistry, Genetics and Molecular Biology 7 18%
Agricultural and Biological Sciences 4 10%
Environmental Science 2 5%
Other 9 23%
Unknown 1 3%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2015.
All research outputs
#2,613,781
of 4,925,544 outputs
Outputs from BMC Complementary and Alternative Medicine
#910
of 1,546 outputs
Outputs of similar age
#84,514
of 146,466 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#41
of 61 outputs
Altmetric has tracked 4,925,544 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,546 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,466 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.