| Title |
The increasing burden and complexity of multi-morbidity and polypharmacy in geriatric HIV patients: a cross sectional study of people aged 65 – 74 years and more than 75 years
|
|---|---|
| Published in |
BMC Geriatrics, April 2018
|
| DOI | 10.1186/s12877-018-0789-0 |
| Pubmed ID | |
| Authors |
G. Guaraldi, A. Malagoli, A. Calcagno, C. Mussi, B. M. Celesia, F. Carli, S. Piconi, G. V. De Socio, A. M. Cattelan, G. Orofino, A. Riva, E. Focà, S. Nozza, G. Di Perri |
| Abstract |
Geriatric Patients Living with HIV/AIDS (GEPPO) is a new prospective observational multicentre cohort consisting of all the HIV-positive geriatric patients being treated at 10 clinics in Italy, and HIV-negative controls attending a single geriatric clinic. The aim of this analysis of the GEPPO cohort was to compare prevalence and risk factors of individual non-communicable diseases (NCD), multi-morbidity (MM) and polypharmacy (PP) amongst HIV positive and HIV negative controls at enrolment into the GEPPO cohort. This cross-sectional study was conducted between June 2015 and May 2016. The duration of HIV infection was subdivided into three intervals: < 10, 10-20 and > 20 years. The NCD diagnoses were based on guidelines defined criteria, including cardiovascular disease, hypertension, type 2 diabetes, chronic kidney disease, dyslipidaemia, chronic obstructive pulmonary disease. MM was classified as the presence of two or more co-morbidities. The medications prescribed for the treatment of comorbidities were collected in both HIV positive and HIV negative group from patient files and were categorized using the Anatomical Therapeutic Chemical (ATC) classification. PP was defined as the presence of five or more drug components other than anti-retroviral agents. The study involved a total of 1573 patient: 1258 HIV positive and 315 HIV negative). The prevalence of individual comorbidities was similar in the two groups with the exception of dyslipidaemia, which was more frequent in the HIV-positive patients (p < 0.01). When the HIV-positive group was stratified based on the duration of HIV infection, most of the co-morbidities were significantly more frequent than in control patients, except for hypertension and cardiovascular disease, while COPD was more prevalent in the control group. MM and PP were both more prevalent in the HIV-positive group, respectively 64% and 37%. MM and PP burden in geriatric HIV positive patients are related to longer duration of HIV-infection rather than older age per se. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 27% |
| Unknown | 8 | 73% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Practitioners (doctors, other healthcare professionals) | 1 | 9% |
| Scientists | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 172 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 13% |
| Researcher | 20 | 12% |
| Student > Bachelor | 16 | 9% |
| Student > Ph. D. Student | 12 | 7% |
| Other | 11 | 6% |
| Other | 39 | 23% |
| Unknown | 52 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 27% |
| Nursing and Health Professions | 20 | 12% |
| Biochemistry, Genetics and Molecular Biology | 7 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Engineering | 5 | 3% |
| Other | 25 | 15% |
| Unknown | 62 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2020.
All research outputs
#1,469,684
of 23,043,346 outputs
Outputs from BMC Geriatrics
#268
of 3,242 outputs
Outputs of similar age
#34,298
of 326,937 outputs
Outputs of similar age from BMC Geriatrics
#8
of 61 outputs
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So far Altmetric has tracked 3,242 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one has done particularly well, scoring higher than 91% of its peers.
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We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.