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Antischistosomal and anti-inflammatory activity of garlic and allicin compared with that of praziquantel in vivo

Overview of attention for article published in BMC Complementary and Alternative Medicine, April 2018
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4 tweeters

Citations

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20 Mendeley
Title
Antischistosomal and anti-inflammatory activity of garlic and allicin compared with that of praziquantel in vivo
Published in
BMC Complementary and Alternative Medicine, April 2018
DOI 10.1186/s12906-018-2191-z
Pubmed ID
Authors

Dina M. Metwally, Ebtesam M. Al-Olayan, Mohammad Alanazi, Sanaa B. Alzahrany, Abdelhabib Semlali

Abstract

Schistosomiasis is an acute and chronic zoonotic parasitic disease caused by trematode worms. The host inflammatory response to schistosome eggs leads to perioval granulomata formation, mainly in the liver and intestine. This study investigated the potential antischistosomal and anti-inflammatory activity of both garlic extract and allicin on liver fibrotic markers in BALB/c mice with schistosomiasis (S. mansoni infection) compared with that of the commonly used drug, praziquantel (PZQ). In this study, 140 female BALB/c mice (7-weeks old) were divided into seven groups with 20 mice each. Six groups were infected with S. mansoni cercariae and treated with garlic, allicin, or PZQ. The seventh group was the negative control. Twenty-four hours after the final treatment, the mice were euthanised and perfused for worm recovery. The liver and intestines were harvested for parasitological and histological assessment and to analyse the proinflammatory cytokine mRNA expression. Prophylactic administration of garlic and allicin to the infected mice significantly reduced the worm burden. Serum concentrations of liver fibrosis markers and proinflammatory cytokines were also reduced. PZQ was the most efficacious for reduction in the number of worms. These results are similar to those normally obtained using PZQ. Crushed garlic homogenate and allicin are potential complementary treatments that may be used with PZQ.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 6 30%
Student > Master 6 30%
Student > Bachelor 3 15%
Researcher 2 10%
Student > Ph. D. Student 2 10%
Other 1 5%
Readers by discipline Count As %
Unspecified 7 35%
Medicine and Dentistry 5 25%
Veterinary Science and Veterinary Medicine 2 10%
Chemistry 2 10%
Neuroscience 2 10%
Other 2 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2018.
All research outputs
#8,133,687
of 12,968,481 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,435
of 2,614 outputs
Outputs of similar age
#161,721
of 268,772 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#1
of 1 outputs
Altmetric has tracked 12,968,481 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,614 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,772 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them