| Title |
Antischistosomal and anti-inflammatory activity of garlic and allicin compared with that of praziquantel in vivo
|
|---|---|
| Published in |
BMC Complementary Medicine and Therapies, April 2018
|
| DOI | 10.1186/s12906-018-2191-z |
| Pubmed ID | |
| Authors |
Dina M. Metwally, Ebtesam M. Al-Olayan, Mohammad Alanazi, Sanaa B. Alzahrany, Abdelhabib Semlali |
| Abstract |
Schistosomiasis is an acute and chronic zoonotic parasitic disease caused by trematode worms. The host inflammatory response to schistosome eggs leads to perioval granulomata formation, mainly in the liver and intestine. This study investigated the potential antischistosomal and anti-inflammatory activity of both garlic extract and allicin on liver fibrotic markers in BALB/c mice with schistosomiasis (S. mansoni infection) compared with that of the commonly used drug, praziquantel (PZQ). In this study, 140 female BALB/c mice (7-weeks old) were divided into seven groups with 20 mice each. Six groups were infected with S. mansoni cercariae and treated with garlic, allicin, or PZQ. The seventh group was the negative control. Twenty-four hours after the final treatment, the mice were euthanised and perfused for worm recovery. The liver and intestines were harvested for parasitological and histological assessment and to analyse the proinflammatory cytokine mRNA expression. Prophylactic administration of garlic and allicin to the infected mice significantly reduced the worm burden. Serum concentrations of liver fibrosis markers and proinflammatory cytokines were also reduced. PZQ was the most efficacious for reduction in the number of worms. These results are similar to those normally obtained using PZQ. Crushed garlic homogenate and allicin are potential complementary treatments that may be used with PZQ. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| United Kingdom | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 93 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 11% |
| Student > Doctoral Student | 10 | 11% |
| Student > Bachelor | 9 | 10% |
| Student > Master | 7 | 8% |
| Lecturer | 6 | 6% |
| Other | 14 | 15% |
| Unknown | 37 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 11% |
| Medicine and Dentistry | 9 | 10% |
| Agricultural and Biological Sciences | 7 | 8% |
| Immunology and Microbiology | 7 | 8% |
| Veterinary Science and Veterinary Medicine | 5 | 5% |
| Other | 14 | 15% |
| Unknown | 41 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2023.
All research outputs
#15,447,558
of 24,489,051 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,759
of 3,843 outputs
Outputs of similar age
#190,165
of 330,991 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#32
of 89 outputs
Altmetric has tracked 24,489,051 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,843 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,991 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.