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The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation

Overview of attention for article published in BMC Complementary and Alternative Medicine, June 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

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4 tweeters

Citations

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4 Dimensions

Readers on

mendeley
35 Mendeley
Title
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation
Published in
BMC Complementary and Alternative Medicine, June 2015
DOI 10.1186/s12906-015-0702-8
Pubmed ID
Authors

Marta Santos Serafim Machado, Hugo Bernardino Ferreira Silva, Raimon Rios, Anaque Pires de Oliveira, Noma Vilany Queiroz Carneiro, Ryan Santos Costa, William Santos Alves, Fabio-Luis Meneses Souza, Eudes da Silva Velozo, Silvana Alves de Souza, Tania Maria Sarmento Silva, Maria Lenise Silva, Lain Carlos Pontes-de-Carvalho, Neuza Maria Alcântara-Neves, Camila Alexandrina Figueiredo

Abstract

The prevalence of allergic diseases such as asthma has significantly increased worldwide, making it a public health concern. There is an urgent need for new anti-inflammatory agents with selective pharmacology and lower toxicity. Plant extracts have been used for centuries in traditional medicine to alleviate inflammatory diseases. In this work, we evaluated the anti-allergic activity of Cymbopogon citratus (Cy), a medicinal herb used by folk medicine to treat asthma. We used a murine model of respiratory allergy to the mite Blomia tropicalis (Bt) and evaluated certain parameters known to be altered in this model. A/J mice were sensitized (100 μg/animal s.c.) and challenged (10 μg/animal i.n.) with Bt mite extract and treated with 60, 120 or 180 mg/kg of Cy standardized hexane extract. The parameters evaluated included: cellular infiltrate in bronchoalveolar lavage (BAL); eosinophil peroxidase activity (EPO); histopathological examination of the lung; serum levels of specific IgE, IgG1 and IgG2a; Th2 cytokine concentrations in BAL and expression of NF-κB. Our results showed that oral administration of a Cy hexane extract (especially 180 mg/Kg) reduced the numbers of leukocytes/eosinophils in BAL; the eosinophil peroxidase activity in BAL; the infiltration of leukocytes in lung tissue; the production of mucus in the respiratory tract; the level of IL-4 in BAL and the nuclear expression of NF-κB. The results presented demonstrate the potential of the Cy hexane extract to modulate allergic asthma; this extract may be an alternative future approach to treat this pathology.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 23%
Student > Ph. D. Student 6 17%
Unspecified 4 11%
Student > Master 4 11%
Other 3 9%
Other 10 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 23%
Pharmacology, Toxicology and Pharmaceutical Science 6 17%
Medicine and Dentistry 5 14%
Unspecified 4 11%
Biochemistry, Genetics and Molecular Biology 3 9%
Other 9 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2015.
All research outputs
#2,601,363
of 6,535,212 outputs
Outputs from BMC Complementary and Alternative Medicine
#765
of 1,732 outputs
Outputs of similar age
#83,534
of 187,979 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#33
of 83 outputs
Altmetric has tracked 6,535,212 research outputs across all sources so far. This one has received more attention than most of these and is in the 59th percentile.
So far Altmetric has tracked 1,732 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 187,979 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.