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The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation

Overview of attention for article published in BMC Complementary Medicine and Therapies, June 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

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65 Mendeley
Title
The anti-allergic activity of Cymbopogon citratus is mediated via inhibition of nuclear factor kappa B (Nf-Κb) activation
Published in
BMC Complementary Medicine and Therapies, June 2015
DOI 10.1186/s12906-015-0702-8
Pubmed ID
Authors

Marta Santos Serafim Machado, Hugo Bernardino Ferreira Silva, Raimon Rios, Anaque Pires de Oliveira, Noma Vilany Queiroz Carneiro, Ryan Santos Costa, William Santos Alves, Fabio-Luis Meneses Souza, Eudes da Silva Velozo, Silvana Alves de Souza, Tania Maria Sarmento Silva, Maria Lenise Silva, Lain Carlos Pontes-de-Carvalho, Neuza Maria Alcântara-Neves, Camila Alexandrina Figueiredo

Abstract

The prevalence of allergic diseases such as asthma has significantly increased worldwide, making it a public health concern. There is an urgent need for new anti-inflammatory agents with selective pharmacology and lower toxicity. Plant extracts have been used for centuries in traditional medicine to alleviate inflammatory diseases. In this work, we evaluated the anti-allergic activity of Cymbopogon citratus (Cy), a medicinal herb used by folk medicine to treat asthma. We used a murine model of respiratory allergy to the mite Blomia tropicalis (Bt) and evaluated certain parameters known to be altered in this model. A/J mice were sensitized (100 μg/animal s.c.) and challenged (10 μg/animal i.n.) with Bt mite extract and treated with 60, 120 or 180 mg/kg of Cy standardized hexane extract. The parameters evaluated included: cellular infiltrate in bronchoalveolar lavage (BAL); eosinophil peroxidase activity (EPO); histopathological examination of the lung; serum levels of specific IgE, IgG1 and IgG2a; Th2 cytokine concentrations in BAL and expression of NF-κB. Our results showed that oral administration of a Cy hexane extract (especially 180 mg/Kg) reduced the numbers of leukocytes/eosinophils in BAL; the eosinophil peroxidase activity in BAL; the infiltration of leukocytes in lung tissue; the production of mucus in the respiratory tract; the level of IL-4 in BAL and the nuclear expression of NF-κB. The results presented demonstrate the potential of the Cy hexane extract to modulate allergic asthma; this extract may be an alternative future approach to treat this pathology.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 64 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 20%
Student > Ph. D. Student 10 15%
Researcher 7 11%
Other 4 6%
Student > Doctoral Student 3 5%
Other 12 18%
Unknown 16 25%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 13 20%
Agricultural and Biological Sciences 10 15%
Medicine and Dentistry 9 14%
Biochemistry, Genetics and Molecular Biology 5 8%
Immunology and Microbiology 3 5%
Other 9 14%
Unknown 16 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2015.
All research outputs
#12,732,710
of 22,808,725 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,352
of 3,630 outputs
Outputs of similar age
#116,294
of 266,602 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#21
of 85 outputs
Altmetric has tracked 22,808,725 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,630 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,602 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.