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Evaluation of anthelmintic potential of the Ethiopian medicinal plant Embelia schimperi Vatke in vivo and in vitro against some intestinal parasites

Overview of attention for article published in BMC Complementary and Alternative Medicine, June 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

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3 tweeters

Citations

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8 Dimensions

Readers on

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33 Mendeley
Title
Evaluation of anthelmintic potential of the Ethiopian medicinal plant Embelia schimperi Vatke in vivo and in vitro against some intestinal parasites
Published in
BMC Complementary and Alternative Medicine, June 2015
DOI 10.1186/s12906-015-0711-7
Pubmed ID
Authors

Yared Debebe, Mesfin Tefera, Walelign Mekonnen, Dawit Abebe, Samuel Woldekidan, Abiy Abebe, Yehualashet Belete, Temesgen Menberu, Bethelhem Belayneh, Berhanu Tesfaye, Ibrahim Nasir, Kidist Yirsaw, Hirut Basha, Asrat Dawit, Asfaw Debella

Abstract

Embelia schimperi has been used for the treatment of intestinal parasites especially tapeworm infestations for centuries in Ethiopia. However, there is lack of scientific based evidences regarding the efficacy, safety and phytochemical analysis of this plant despite its frequent use as an anthelmintic. This study has therefore evaluated the efficacy and acute toxicity of E. schimperi thereby generating relevant preclinical information. The anthelmintic activities of the crude hydroalcoholic extract of E. schimperi and the isolated compound, embelin, were conducted using in vivo and in vitro models against the dwarf tapeworm, Hymenolepis nana, and the hookworm, Necator americanus, respectively. LD50 of the crude hydroalcoholic extract was determined using Swiss albino mice following the OECD guidelines. Chemical characterization of the isolated embelin was conducted using UV-spectroscopy, HPLC and NMR. In the acute toxicity study no prominent signs of toxicity and mortality were recorded among the experimental animals at the highest administered dose. Hence the LD50 of the plant was found to be higher than 5000 mg/kg. In vivo cestocidal activity of the crude hydroalcoholic extract of E. schimperi showed 100 % parasite clearance at 1000 mg/kg, while the diammonium salt of embelin showed 85.3 % parasite clearance at 750 mg/kg. The in vitro anthelminthic activity study revealed that the LC50 value of the crude extract and albendazole were 228.7 and 51.33 μg/mL, respectively. The results clearly indicated that the hydroalcoholic extract of E. schimperi and the diammonium salt of the isolated compound embelin had anthelmintic activity against hookworm larva in vitro and H. nana in vivo. Hence the findings of this study showed Embelia schimperi appears to possess some anthelmintic activity that may support the usage of these plants by local traditional healers to treat helminthic infestations.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ethiopia 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Unspecified 8 24%
Student > Bachelor 7 21%
Researcher 7 21%
Student > Master 4 12%
Student > Doctoral Student 2 6%
Other 5 15%
Readers by discipline Count As %
Unspecified 9 27%
Agricultural and Biological Sciences 7 21%
Engineering 4 12%
Nursing and Health Professions 2 6%
Immunology and Microbiology 2 6%
Other 9 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2016.
All research outputs
#2,902,880
of 7,185,566 outputs
Outputs from BMC Complementary and Alternative Medicine
#727
of 1,796 outputs
Outputs of similar age
#84,880
of 222,976 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#28
of 86 outputs
Altmetric has tracked 7,185,566 research outputs across all sources so far. This one has received more attention than most of these and is in the 58th percentile.
So far Altmetric has tracked 1,796 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,976 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.