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Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model

Overview of attention for article published in BMC Complementary and Alternative Medicine, June 2015
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Title
Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model
Published in
BMC Complementary and Alternative Medicine, June 2015
DOI 10.1186/s12906-015-0694-4
Pubmed ID
Authors

Lívia G. Castilhos, João F. P. Rezer, Jader B. Ruchel, Maria Luiza Thorstenberg, Jeandre A. dos S. Jaques, Josiane B. Schlemmer, Pedro H. Doleski, Mateus F. Rossato, Mariane A. da Silva, Emerson André Casalli, Ritiel Corrêa da Cruz, Juliano Ferreira, Margareth L. Athayde, Jamile F. Gonçalves, Daniela B. R. Leal

Abstract

Considering that adjuvant arthritis is an experimental model of arthritis widely used for preclinical testing of numerous anti-arthritic agents, which were taken by a large number of patients worldwide, it is of great interest to investigate the therapeutic action of compounds with anti-inflammatory properties, such as Uncaria tomentosa extract. Moreover, there are no studies demonstrating the effect of U. tomentosa on the metabolism of adenine nucleotides published so far. Thus, the purpose of the present study is to investigate the effects of U. tomentosa extract on E-NTPDase and E-ADA activities in lymphocytes of Complete Freund's Adjuvant (CFA) arthritis induced rats. To evaluate the effect of U. tomentosa extract on the activity of E-NTPDase and ADA in lymphocytes, the rats were submitted to an experimental adjuvant arthritis model. Peripheral lymphocytes were isolated and E-NTPDase and E-ADA activities were determined. Data were analyzed by a one- or two-way ANOVA. Post hoc analyses were carried out by the Student-Newman-Keuls (SNK) Multiple Comparison Test. E-NTPDase activity was increased in arthritic untreated. Arthritic rats which received U. tomentosa extract, presented similar results to the control group. However, results obtained for adenosine hydrolysis by E-ADA were not altered in arthritic rats. U. tomentosa extract did not alter E-NTPDase and E-ADA activity in healthy animals. The present investigation supports the hypothesis that the increased E-NTPDase activity verified in arthritic rats might be an attempt to maintain basal levels of ATP and ADP in the extracellular medium, since the arthritis induction causes tissue damage and, consequently, large amounts of ATP are released into this milieu. Also, it highlights the possibility to use U. tomentosa extract as an adjuvant to treat arthritis.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 24%
Researcher 3 12%
Student > Ph. D. Student 3 12%
Professor 2 8%
Student > Postgraduate 2 8%
Other 9 36%
Readers by discipline Count As %
Medicine and Dentistry 5 20%
Biochemistry, Genetics and Molecular Biology 5 20%
Pharmacology, Toxicology and Pharmaceutical Science 3 12%
Business, Management and Accounting 2 8%
Unspecified 2 8%
Other 8 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2019.
All research outputs
#12,121,417
of 13,657,928 outputs
Outputs from BMC Complementary and Alternative Medicine
#2,244
of 2,776 outputs
Outputs of similar age
#190,119
of 229,787 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#1
of 1 outputs
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So far Altmetric has tracked 2,776 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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