| Title |
Simultaneous exposure to multiple heavy metals and glyphosate may contribute to Sri Lankan agricultural nephropathy
|
|---|---|
| Published in |
BMC Nephrology, July 2015
|
| DOI | 10.1186/s12882-015-0109-2 |
| Pubmed ID | |
| Authors |
Channa Jayasumana, Sarath Gunatilake, Sisira Siribaddana |
| Abstract |
Sri Lankan Agricultural Nephropathy (SAN), a new form of chronic kidney disease among paddy farmers was first reported in 1994. It has now become the most debilitating public health issue in the dry zone of Sri Lanka. Previous studies showed SAN is a tubulo-interstitial type nephropathy and exposure to arsenic and cadmium may play a role in pathogenesis of the disease. Urine samples of patients with SAN (N = 10) from Padavi-Sripura, a disease endemic area, and from two sets of controls, one from healthy participants (N = 10) from the same endemic area and the other from a non-endemic area (N = 10; Colombo district) were analyzed for 19 heavy metals and for the presence of the pesticide- glyphosate. In both cases and the controls who live in the endemic region, median concentrations of urinary Sb, As, Cd, Co, Pb, Mn, Ni, Ti and V exceed the reference range. With the exception of Mo in patients and Al, Cu, Mo, Se, Ti and Zn in endemic controls, creatinine adjusted values of urinary heavy metals and glyphosate were significantly higher when compared to non-endemic controls. Creatinine unadjusted values were significant higher for 14 of the 20 chemicals studied in endemic controls and 7 in patients, compared to non-endemic controls. The highest urinary glyphosate concentration was recorded in SAN patients (range 61.0-195.1 μg/g creatinine). People in disease endemic area exposed to multiple heavy metals and glyphosate. Results are supportive of toxicological origin of SAN that is confined to specific geographical areas. Although we could not localize a single nephrotoxin as the culprit for SAN, multiple heavy metals and glyphosates may play a role in the pathogenesis. Heavy metals excessively present in the urine samples of patients with SAN are capable of causing damage to kidneys. Synergistic effects of multiple heavy metals and agrochemicals may be nephrotoxic. |
X Demographics
The data shown below were collected from the profiles of 37 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 16% |
| Switzerland | 3 | 8% |
| France | 3 | 8% |
| India | 2 | 5% |
| Chile | 2 | 5% |
| New Zealand | 1 | 3% |
| Norway | 1 | 3% |
| Bosnia and Herzegovina | 1 | 3% |
| Germany | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 17 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 86% |
| Practitioners (doctors, other healthcare professionals) | 4 | 11% |
| Scientists | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 228 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sri Lanka | 4 | 2% |
| United States | 1 | <1% |
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 221 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 35 | 15% |
| Student > Ph. D. Student | 27 | 12% |
| Student > Master | 25 | 11% |
| Researcher | 25 | 11% |
| Student > Postgraduate | 12 | 5% |
| Other | 42 | 18% |
| Unknown | 62 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 37 | 16% |
| Agricultural and Biological Sciences | 26 | 11% |
| Chemistry | 19 | 8% |
| Environmental Science | 13 | 6% |
| Nursing and Health Professions | 11 | 5% |
| Other | 52 | 23% |
| Unknown | 70 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 59. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2023.
All research outputs
#742,089
of 25,867,969 outputs
Outputs from BMC Nephrology
#27
of 2,797 outputs
Outputs of similar age
#8,387
of 278,251 outputs
Outputs of similar age from BMC Nephrology
#1
of 46 outputs
Altmetric has tracked 25,867,969 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,797 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.