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Analysis of glycation induced protein cross-linking inhibitory effects of some antidiabetic plants and spices

Overview of attention for article published in BMC Complementary and Alternative Medicine, June 2015
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58 Mendeley
Title
Analysis of glycation induced protein cross-linking inhibitory effects of some antidiabetic plants and spices
Published in
BMC Complementary and Alternative Medicine, June 2015
DOI 10.1186/s12906-015-0689-1
Pubmed ID
Authors

Handunge Kumudu Irani Perera, Charith Sandaruwan Handuwalage

Abstract

Protein cross-linking which occurs towards the latter part of protein glycation is implicated in the development of chronic diabetic complications. Glycation induced protein cross-linking inhibitory effects of nine antidiabetic plants and three spices were evaluated in this study using a novel, simple, electrophoresis based method. Methanol extracts of thirteen plants including nine antidiabetic plants and three spices were used. Lysozyme and fructose were incubated at 37 °C in the presence or absence of different concentrations of plant extracts up to 31 days. Standard glycation inhibitor aminoguanidine and other appropriate controls were included. A recently established sodium dodecyl polyacrylamide gel electrophoresis (SDS-PAGE) method was used to detect the products of protein cross-linking in the incubation mixtures. High molecular weight protein products representing the dimer, trimer and tetramer of lysozyme were detected in the presence of fructose. Among the nine antidiabetic plants, seven showed glycation induced protein cross-linking inhibitory effects namely Ficus racemosa (FR) stem bark, Gymnema sylvestre (GS) leaves, Musa paradisiaca (MP) yam, Phyllanthus debilis (PD) whole plant, Phyllanthus emblica (PE) fruit, Pterocarpus marsupium (PM) latex and Tinospora cordifolia (TC) leaves. Inhibition observed with Coccinia grandis (CG) leaves and Strychnos potatorum (SP) seeds were much low. Leaves of Gymnema lactiferum (GL), the plant without known antidiabetic effects showed the lowest inhibition. All three spices namely Coriandrum sativum (CS) seeds, Cinnamomum zeylanicum (CZ) bark and Syzygium aromaticum (SA) flower buds showed cross-link inhibitory effects with higher effects in CS and SA. PD, PE, PM, CS and SA showed almost complete inhibition on the formation of cross-linking with 25 μg/ml extracts. Methanol extracts of PD, PE, PM, CS and SA have shown promising inhibitory effects on glycation induced protein cross-linking.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
United States 1 2%
Unknown 56 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 19%
Student > Bachelor 8 14%
Researcher 7 12%
Unspecified 5 9%
Student > Ph. D. Student 5 9%
Other 22 38%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 22%
Medicine and Dentistry 11 19%
Unspecified 10 17%
Biochemistry, Genetics and Molecular Biology 8 14%
Pharmacology, Toxicology and Pharmaceutical Science 7 12%
Other 9 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2016.
All research outputs
#6,155,043
of 8,515,357 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,383
of 2,148 outputs
Outputs of similar age
#145,368
of 232,874 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#51
of 72 outputs
Altmetric has tracked 8,515,357 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,148 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,874 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.