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A considerable proportion of CRF01_AE strains in China originated from circulating intrasubtype recombinant forms (CIRF)

Overview of attention for article published in BMC Infectious Diseases, November 2015
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3 tweeters

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5 Dimensions

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6 Mendeley
Title
A considerable proportion of CRF01_AE strains in China originated from circulating intrasubtype recombinant forms (CIRF)
Published in
BMC Infectious Diseases, November 2015
DOI 10.1186/s12879-015-1273-5
Pubmed ID
Authors

Lei Jia, Tao Gui, Lin Li, Siyang Liu, Hanping Li, Zuoyi Bao, Xiaolin Wang, Daomin Zhuang, Tianyi Li, Jingwan Han, Yongjian Liu, Jingyun Li

Abstract

In this study, the prevalence of HIV-1 CRF01_AE intrasubtype recombinants in China is estimated and their contributions to the epidemic are explored. Available HIV-1 complete genomes of CRF01_AE were retrieved from the HIV database. The two alignments were evaluated with RDP3. Recombinants were defined as cases in which the recombination signal was supported by at least 3 methods with P-values of ≤0.05 after Bonferroni correction for multiple comparisons implemented in RDP3. Phylogenetic analysis was performed to further investigate the role of intrasubtype recombinants in epidemics. Here, 124 out of the 339 sequences from around the world (36.6 %) showed significant evidence of recombination. Here, 84 of these recombinants were from China, accounting for 54.9 % of local total sequences (84 out of 153). The results indicated non-negligible levels of intrasubtype recombination. Subsequent phylogenetic analysis indicated that a considerable proportion of CRF01_AE strains in China originated from circulating intrasubtype recombinant forms. Three large, well-supported intrasubtype recombinants clusters were identified here. Through a survey of risk factors and sampling cities and provinces, cluster I and cluster II were found to be prevalent primarily among men who have sex with men in major northern cities. Cluster III was prevalent among heterosexuals and intravenous drug users in southern and southwestern provinces. The current work highlighted the remarkable prevalence of intrasubtype recombination within the CRF01_AE epidemic and emphasized the value of intrasubtype recombinants, which came to circulate in the same manner as intersubtype recombinants.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 33%
Researcher 1 17%
Student > Ph. D. Student 1 17%
Unknown 2 33%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Nursing and Health Professions 1 17%
Unknown 3 50%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2016.
All research outputs
#4,165,701
of 7,940,332 outputs
Outputs from BMC Infectious Diseases
#2,010
of 3,568 outputs
Outputs of similar age
#117,073
of 224,822 outputs
Outputs of similar age from BMC Infectious Diseases
#82
of 147 outputs
Altmetric has tracked 7,940,332 research outputs across all sources so far. This one is in the 27th percentile – i.e., 27% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,568 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
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We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.