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Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway

Overview of attention for article published in Journal of Neuroinflammation, June 2015
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

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1 patent
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2 Facebook pages

Citations

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56 Dimensions

Readers on

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62 Mendeley
Title
Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway
Published in
Journal of Neuroinflammation, June 2015
DOI 10.1186/s12974-015-0344-2
Pubmed ID
Authors

Sun Mi Gu, Mi Hee Park, Chul Ju Hwang, Ho Sueb Song, Ung Soo Lee, Sang Bae Han, Ki Wan Oh, Young Wan Ham, Min Jong Song, Dong Ju Son, Jin Tae Hong

Abstract

Accumulation of beta-amyloid and neuroinflammation trigger Alzheimer's disease. We previously found that lipopolysaccharide (LPS) caused neuroinflammation with concomitant accumulation of beta-amyloid peptides leading to memory loss. A variety of anti-inflammatory compounds inhibiting nuclear factor kappaB (NF-κB) activation have showed efficacy to hinder neuroinflammation and amyloidogenesis. We also found that bee venom (BV) inhibits NF-κB. A mouse model of LPS-induced memory loss used administration of BV (0.8 and 1.6 μg/kg/day, i.p.) to ICR mice for 7 days before injection of LPS (2.5 mg/kg/day, i.p.). Memory loss was assessed using a Morris water maze test and passive avoidance test. For in vitro study, we treated BV (0.5, 1, and 2 μg/mL) to astrocytes and microglial BV-2 cells with LPS (1 μg/mL). We found that BV inhibited LPS-induced memory loss determined by behavioral tests as well as cell death. BV also inhibited LPS-induced increases in the level of beta-amyloid (Aβ), β-and γ-secretases activities, NF-κB and its DNA-binding activity and expression of APP, and BACE1 and neuroinflammation proteins (COX-2, iNOS, GFAP and IBA-1) in the brain and cultured cells. In addition, pull-down assay and molecular modeling showed that BV binds to NF-κB. BV attenuates LPS-induced amyloidogenesis, neuroinflammation, and therefore memory loss via inhibiting NF-κB signaling pathway. Thus, BV could be useful for treatment of Alzheimer's disease.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 61 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 18%
Student > Bachelor 11 18%
Student > Master 11 18%
Researcher 8 13%
Student > Doctoral Student 3 5%
Other 7 11%
Unknown 11 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 16%
Neuroscience 8 13%
Medicine and Dentistry 8 13%
Biochemistry, Genetics and Molecular Biology 7 11%
Pharmacology, Toxicology and Pharmaceutical Science 6 10%
Other 9 15%
Unknown 14 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 December 2022.
All research outputs
#7,144,201
of 23,332,901 outputs
Outputs from Journal of Neuroinflammation
#1,189
of 2,697 outputs
Outputs of similar age
#82,039
of 264,659 outputs
Outputs of similar age from Journal of Neuroinflammation
#17
of 49 outputs
Altmetric has tracked 23,332,901 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 2,697 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,659 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.