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Protective effects of Arctium lappa L. root extracts (AREs) on high fat diet induced quail atherosclerosis

Overview of attention for article published in BMC Complementary and Alternative Medicine, January 2016
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Title
Protective effects of Arctium lappa L. root extracts (AREs) on high fat diet induced quail atherosclerosis
Published in
BMC Complementary and Alternative Medicine, January 2016
DOI 10.1186/s12906-016-0987-2
Pubmed ID
Authors

Zhi Wang, Ping Li, Chenjing Wang, Qixiao Jiang, Lei Zhang, Yu Cao, Weizhen Zhong, Chunbo Wang

Abstract

This study was designed to evaluate the protective effects of Arctium lappa L. root extracts (AREs) from different extraction methods (aqueous, ethanol, chloroform and flavone) on atherosclerosis. Quails (Coturnix coturnix) were subjected to high fat diet, with or without one of the four different AREs or positive control simvastatin. Blood samples were collected before treatment, after 4.5 weeks or ten weeks to assess lipid profile (Levels of total cholesterol (TC), Triacylglycerol (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL)). After ten weeks, the serum levels of nitric oxide (NO) as well as antioxidant and pro-oxidative status (Levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), nicotinamide adenine dinucleotide phosphate (NADPH) and glutathione peroxidase (GSH-Px)) were measured. Furthermore, aortas were collected after ten weeks treatment, aorta lipid contents (TC, TG and LDL) were assessed, and histology was used to confirm atherosclerotic changes. The results indicated that high fat diet significantly deteriorated lipid profile and antioxidant status in quail serum, while all the extracts significantly reverted the changes similar to simvastatin. Aorta lipid profile assessment revealed similar results. Histology on aortas from quails treated for ten weeks confirmed atherosclerotic changes in high fat diet group, while the extracts significantly alleviated the atherosclerotic changes similar to simvastatin. Among the different extracts, flavones fraction exerted best protective effects. Our data suggest that the protective effects of AREs were medicated via hypolipidemic and anti-oxidant effects. Underlying molecular mechanisms are under investigation.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 30%
Researcher 5 25%
Student > Doctoral Student 2 10%
Student > Bachelor 2 10%
Student > Postgraduate 1 5%
Other 4 20%
Readers by discipline Count As %
Medicine and Dentistry 5 25%
Agricultural and Biological Sciences 5 25%
Unspecified 3 15%
Chemistry 2 10%
Nursing and Health Professions 2 10%
Other 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2016.
All research outputs
#6,229,789
of 8,204,367 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,472
of 2,064 outputs
Outputs of similar age
#220,375
of 318,678 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#60
of 91 outputs
Altmetric has tracked 8,204,367 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,064 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,678 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.