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Incidence and prevalence of total joint replacements due to osteoarthritis in the elderly: risk factors and factors associated with late life prevalence in the AGES-Reykjavik Study

Overview of attention for article published in BMC Musculoskeletal Disorders, January 2016
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55 Mendeley
Title
Incidence and prevalence of total joint replacements due to osteoarthritis in the elderly: risk factors and factors associated with late life prevalence in the AGES-Reykjavik Study
Published in
BMC Musculoskeletal Disorders, January 2016
DOI 10.1186/s12891-016-0864-7
Pubmed ID
Authors

Helgi Jonsson, Sigurbjorg Olafsdottir, Solveig Sigurdardottir, Thor Aspelund, Gudny Eiriksdottir, Sigurdur Sigurdsson, Tamara B. Harris, Lenore Launer, Vilmundur Gudnason

Abstract

Total joint replacements (TJRs) should be considered as one of few definite endpoints in osteoarthritis research. We analyzed factors associated with late-life prevalence and risk factors for incidence of TJRs due to osteoarthritis in a population based cohort. After exclusion of inflammatory arthritis and fractures as causes of TJR, 5170 participants in the AGES-Reykjavik Study (mean age (SD) 76.4(6), 58 % females) were included for osteoarthritis studies. Three thousand one hundred thirty-three of them had a follow-up visit 5 years later. The prevalence of having at least one joint replacement operation due to OA was 13.6 % and the yearly incidence was 1.4 %/year during the five-year follow-up. Factors positively associated with late life prevalence of TJR included BMI, hand OA severity, female gender, finger length ratio and spine BMD. Risk factors for TJRs in the incidence group were symptoms at initial visit, prior TJR in the contralateral joint and BMI. Much stronger associations were seen for TKR than for THR with discriminatory analysis showing an AUC 0.71 for late life prevalence and 0.84 for the incidence. This study illustrates the importance of the different information expressed by late life prevalence vs. incidence on the factors associated with severe osteoarthritis of the knee and hip. The observation that prior TJR is a risk factor for subsequent TJR in the contralateral joint has not been described previously. The high power predictions for TKR suggest that a predictive model may be feasible, particularly if it can be extended by the addition of further predictive variables, perhaps through genetic, biomarker or imaging data.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Iceland 1 2%
Unknown 53 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 15%
Student > Master 7 13%
Student > Ph. D. Student 7 13%
Researcher 6 11%
Other 4 7%
Other 11 20%
Unknown 12 22%
Readers by discipline Count As %
Medicine and Dentistry 17 31%
Nursing and Health Professions 4 7%
Computer Science 3 5%
Biochemistry, Genetics and Molecular Biology 2 4%
Immunology and Microbiology 2 4%
Other 9 16%
Unknown 18 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2016.
All research outputs
#4,993,821
of 7,012,411 outputs
Outputs from BMC Musculoskeletal Disorders
#1,365
of 1,911 outputs
Outputs of similar age
#199,751
of 317,437 outputs
Outputs of similar age from BMC Musculoskeletal Disorders
#56
of 81 outputs
Altmetric has tracked 7,012,411 research outputs across all sources so far. This one is in the 25th percentile – i.e., 25% of other outputs scored the same or lower than it.
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