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Public availability of results of observational studies evaluating an intervention registered at ClinicalTrials.gov

Overview of attention for article published in BMC Medicine, January 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)

Mentioned by

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8 tweeters

Citations

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11 Dimensions

Readers on

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14 Mendeley
Title
Public availability of results of observational studies evaluating an intervention registered at ClinicalTrials.gov
Published in
BMC Medicine, January 2016
DOI 10.1186/s12916-016-0551-4
Pubmed ID
Authors

Marie Baudart, Philippe Ravaud, Gabriel Baron, Agnes Dechartres, Romana Haneef, Isabelle Boutron

Abstract

Observational studies are essential for assessing safety. The aims of this study were to evaluate whether results of observational studies evaluating an intervention with safety outcome(s) registered at ClinicalTrials.gov were published and, if not, whether they were available through posting on ClinicalTrials.gov or the sponsor website. We identified a cohort of observational studies with safety outcome(s) registered on ClinicalTrials.gov after October 1, 2007, and completed between October 1, 2007, and December 31, 2011. We systematically searched PubMed for a publication, as well as ClinicalTrials.gov and the sponsor website for results. The main outcomes were the time to the first publication in journals and to the first public availability of the study results (i.e. published or posted on ClinicalTrials.gov or the sponsor website). For all studies with results publicly available, we evaluated the completeness of reporting (i.e. reported with the number of events per arm) of safety outcomes. We identified 489 studies; 334 (68 %) were partially or completely funded by industry. Results for only 189 (39 %, i.e. 65 % of the total target number of participants) were published at least 30 months after the study completion. When searching other data sources, we obtained the results for 53 % (n = 158; i.e. 93 % of the total target number of participants) of unpublished studies; 31 % (n = 94) were posted on ClinicalTrials.gov and 21 % (n = 64) on the sponsor website. As compared with non-industry-funded studies, industry-funded study results were less likely to be published but not less likely to be publicly available. Of the 242 studies with a primary outcome recorded as a safety issue, all these outcomes were adequately reported in 86 % (114/133) when available in a publication, 91 % (62/68) when available on ClinicalTrials.gov, and 80 % (33/41) when available on the sponsor website. Only 39 % of observational studies evaluating an intervention with safety outcome(s) registered at ClinicalTrials.gov had their results published at least 30 months after study completion. The registration of these observational studies allowed searching other sources (results posted at ClinicalTrials.gov and sponsor website) and obtaining results for half of unpublished studies and 93 % of the total target number of participants.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Professor 4 29%
Other 4 29%
Librarian 1 7%
Student > Bachelor 1 7%
Student > Ph. D. Student 1 7%
Other 2 14%
Unknown 1 7%
Readers by discipline Count As %
Medicine and Dentistry 10 71%
Sports and Recreations 1 7%
Arts and Humanities 1 7%
Unknown 2 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2016.
All research outputs
#3,459,816
of 14,090,522 outputs
Outputs from BMC Medicine
#1,520
of 2,207 outputs
Outputs of similar age
#78,790
of 338,108 outputs
Outputs of similar age from BMC Medicine
#1
of 1 outputs
Altmetric has tracked 14,090,522 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,207 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,108 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them