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Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature

Overview of attention for article published in BMC Medicine, February 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)

Mentioned by

news
9 news outlets
blogs
1 blog
twitter
117 tweeters
facebook
3 Facebook pages

Citations

dimensions_citation
119 Dimensions

Readers on

mendeley
277 Mendeley
Title
Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature
Published in
BMC Medicine, February 2016
DOI 10.1186/s12916-016-0553-2
Pubmed ID
Authors

Igho J. Onakpoya, Carl J. Heneghan, Jeffrey K. Aronson

Abstract

There have been no studies of the patterns of post-marketing withdrawals of medicinal products to which adverse reactions have been attributed. We identified medicinal products that were withdrawn because of adverse drug reactions, examined the evidence to support such withdrawals, and explored the pattern of withdrawals across countries. We searched PubMed, Google Scholar, the WHO's database of drugs, the websites of drug regulatory authorities, and textbooks. We included medicinal products withdrawn between 1950 and 2014 and assessed the levels of evidence used in making withdrawal decisions using the criteria of the Oxford Centre for Evidence Based Medicine. We identified 462 medicinal products that were withdrawn from the market between 1953 and 2013, the most common reason being hepatotoxicity. The supporting evidence in 72 % of cases consisted of anecdotal reports. Only 43 (9.34 %) drugs were withdrawn worldwide and 179 (39 %) were withdrawn in one country only. Withdrawal was significantly less likely in Africa than in other continents (Europe, the Americas, Asia, and Australasia and Oceania). The median interval between the first reported adverse reaction and the year of first withdrawal was 6 years (IQR, 1-15) and the interval did not consistently shorten over time. There are discrepancies in the patterns of withdrawal of medicinal products from the market when adverse reactions are suspected, and withdrawals are inconsistent across countries. Greater co-ordination among drug regulatory authorities and increased transparency in reporting suspected adverse drug reactions would help improve current decision-making processes.

Twitter Demographics

The data shown below were collected from the profiles of 117 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 277 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 <1%
South Africa 2 <1%
United Kingdom 1 <1%
Germany 1 <1%
Brazil 1 <1%
Finland 1 <1%
Unknown 269 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 60 22%
Student > Ph. D. Student 52 19%
Student > Master 45 16%
Student > Bachelor 33 12%
Other 22 8%
Other 65 23%
Readers by discipline Count As %
Medicine and Dentistry 65 23%
Pharmacology, Toxicology and Pharmaceutical Science 62 22%
Unspecified 33 12%
Biochemistry, Genetics and Molecular Biology 30 11%
Agricultural and Biological Sciences 29 10%
Other 58 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 151. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2019.
All research outputs
#96,999
of 13,622,595 outputs
Outputs from BMC Medicine
#95
of 2,154 outputs
Outputs of similar age
#3,483
of 336,840 outputs
Outputs of similar age from BMC Medicine
#1
of 1 outputs
Altmetric has tracked 13,622,595 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,154 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.0. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,840 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them