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Circulating tumor cells in breast cancer: A tool whose time has come of age

Overview of attention for article published in BMC Medicine, April 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

blogs
2 blogs
twitter
1 X user
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
53 Dimensions

Readers on

mendeley
99 Mendeley
citeulike
1 CiteULike
Title
Circulating tumor cells in breast cancer: A tool whose time has come of age
Published in
BMC Medicine, April 2011
DOI 10.1186/1741-7015-9-43
Pubmed ID
Authors

Ramona F Swaby, Massimo Cristofanilli

Abstract

Circulating tumor cells (CTCs) are isolated tumor cells disseminated from the site of disease in metastatic and/or primary cancers, including breast cancer, that can be identified and measured in the peripheral blood of patients. As recent technical advances have rendered it easier to reproducibly and repeatedly sample this population of cells with a high degree of accuracy, these cells represent an attractive surrogate marker of the site of disease. Currently, CTCs are being integrated into clinical trial design as a surrogate for phenotypic and genotypic markers in correlation with development of molecularly targeted therapies. As CTCs play a crucial role in tumor dissemination, translational research is implicating CTCs in several biological processes, including epithelial to mesenchymal transition. In this mini-review, we review CTCs in metastatic breast cancer, and discuss their clinical utility for assessing prognosis and monitoring response to therapy. We will also introduce their utility in pharmacodynamic monitoring for rational selection of molecularly targeted therapies and briefly address how they can help elucidate the biology of cancer metastasis.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 2 2%
United Kingdom 2 2%
India 1 1%
Mexico 1 1%
United States 1 1%
Unknown 92 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 27%
Student > Ph. D. Student 18 18%
Student > Master 13 13%
Student > Bachelor 9 9%
Other 8 8%
Other 13 13%
Unknown 11 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 29%
Medicine and Dentistry 26 26%
Biochemistry, Genetics and Molecular Biology 13 13%
Engineering 8 8%
Psychology 3 3%
Other 7 7%
Unknown 13 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2012.
All research outputs
#1,340,228
of 22,663,150 outputs
Outputs from BMC Medicine
#942
of 3,397 outputs
Outputs of similar age
#5,492
of 109,081 outputs
Outputs of similar age from BMC Medicine
#8
of 39 outputs
Altmetric has tracked 22,663,150 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,397 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,081 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.