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Circulating tumor cells in breast cancer: A tool whose time has come of age

Overview of attention for article published in BMC Medicine, April 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

2 blogs
1 tweeter
1 Wikipedia page


47 Dimensions

Readers on

86 Mendeley
1 CiteULike
Circulating tumor cells in breast cancer: A tool whose time has come of age
Published in
BMC Medicine, April 2011
DOI 10.1186/1741-7015-9-43
Pubmed ID

Ramona F Swaby, Massimo Cristofanilli


Circulating tumor cells (CTCs) are isolated tumor cells disseminated from the site of disease in metastatic and/or primary cancers, including breast cancer, that can be identified and measured in the peripheral blood of patients. As recent technical advances have rendered it easier to reproducibly and repeatedly sample this population of cells with a high degree of accuracy, these cells represent an attractive surrogate marker of the site of disease. Currently, CTCs are being integrated into clinical trial design as a surrogate for phenotypic and genotypic markers in correlation with development of molecularly targeted therapies. As CTCs play a crucial role in tumor dissemination, translational research is implicating CTCs in several biological processes, including epithelial to mesenchymal transition. In this mini-review, we review CTCs in metastatic breast cancer, and discuss their clinical utility for assessing prognosis and monitoring response to therapy. We will also introduce their utility in pharmacodynamic monitoring for rational selection of molecularly targeted therapies and briefly address how they can help elucidate the biology of cancer metastasis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 2 2%
United Kingdom 2 2%
India 1 1%
Mexico 1 1%
Spain 1 1%
United States 1 1%
Unknown 78 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 29%
Student > Ph. D. Student 17 20%
Student > Master 13 15%
Other 8 9%
Student > Bachelor 7 8%
Other 12 14%
Unknown 4 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 33%
Medicine and Dentistry 25 29%
Biochemistry, Genetics and Molecular Biology 10 12%
Engineering 8 9%
Chemistry 3 3%
Other 6 7%
Unknown 6 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2012.
All research outputs
of 12,517,134 outputs
Outputs from BMC Medicine
of 2,010 outputs
Outputs of similar age
of 116,792 outputs
Outputs of similar age from BMC Medicine
of 30 outputs
Altmetric has tracked 12,517,134 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,010 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.9. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,792 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.