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Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease.

Overview of attention for article published in Journal of Neuroinflammation, April 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
90 Dimensions

Readers on

mendeley
122 Mendeley
citeulike
1 CiteULike
Title
Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease.
Published in
Journal of Neuroinflammation, April 2008
DOI 10.1186/1742-2094-5-12
Pubmed ID
Authors

Chen X, Gawryluk JW, Wagener JF, Ghribi O, Geiger JD, Xuesong Chen, Jeremy W Gawryluk, John F Wagener, Othman Ghribi, Jonathan D Geiger

Abstract

High levels of serum cholesterol and disruptions of the blood brain barrier (BBB) have all been implicated as underlying mechanisms in the pathogenesis of Alzheimer's disease. Results from studies conducted in animals and humans suggest that caffeine might be protective against Alzheimer's disease but by poorly understood mechanisms. Using rabbits fed a cholesterol-enriched diet, we tested our hypothesis that chronic ingestion of caffeine protects against high cholesterol diet-induced disruptions of the BBB. New Zealand rabbits were fed a 2% cholesterol-enriched diet, and 3 mg caffeine was administered daily in drinking water for 12 weeks. Total cholesterol and caffeine concentrations from blood were measured. Olfactory bulbs (and for some studies hippocampus and cerebral cortex as well) were evaluated for BBB leakage, BBB tight junction protein expression levels, activation of astrocytes, and microglia density using histological, immunostaining and immunoblotting techniques. We found that caffeine blocked high cholesterol diet-induced increases in extravasation of IgG and fibrinogen, increases in leakage of Evan's blue dye, decreases in levels of the tight junction proteins occludin and ZO-1, increases in astrocytes activation and microglia density where IgG extravasation was present. Chronic ingestion of caffeine protects against high cholesterol diet-induced increases in disruptions of the BBB, and caffeine and drugs similar to caffeine might be useful in the treatment of Alzheimer's disease.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
India 1 <1%
Colombia 1 <1%
Canada 1 <1%
Mexico 1 <1%
Portugal 1 <1%
Unknown 114 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 17%
Student > Master 18 15%
Researcher 18 15%
Student > Bachelor 18 15%
Student > Doctoral Student 9 7%
Other 26 21%
Unknown 12 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 28%
Medicine and Dentistry 23 19%
Neuroscience 15 12%
Biochemistry, Genetics and Molecular Biology 10 8%
Psychology 6 5%
Other 15 12%
Unknown 19 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2020.
All research outputs
#856,407
of 16,206,553 outputs
Outputs from Journal of Neuroinflammation
#63
of 2,016 outputs
Outputs of similar age
#5,532
of 126,042 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 8 outputs
Altmetric has tracked 16,206,553 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,016 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 126,042 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them