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Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease

Overview of attention for article published in Journal of Neuroinflammation, April 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
3 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
104 Dimensions

Readers on

mendeley
135 Mendeley
citeulike
1 CiteULike
Title
Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease
Published in
Journal of Neuroinflammation, April 2008
DOI 10.1186/1742-2094-5-12
Pubmed ID
Authors

Xuesong Chen, Jeremy W Gawryluk, John F Wagener, Othman Ghribi, Jonathan D Geiger

Abstract

High levels of serum cholesterol and disruptions of the blood brain barrier (BBB) have all been implicated as underlying mechanisms in the pathogenesis of Alzheimer's disease. Results from studies conducted in animals and humans suggest that caffeine might be protective against Alzheimer's disease but by poorly understood mechanisms. Using rabbits fed a cholesterol-enriched diet, we tested our hypothesis that chronic ingestion of caffeine protects against high cholesterol diet-induced disruptions of the BBB. New Zealand rabbits were fed a 2% cholesterol-enriched diet, and 3 mg caffeine was administered daily in drinking water for 12 weeks. Total cholesterol and caffeine concentrations from blood were measured. Olfactory bulbs (and for some studies hippocampus and cerebral cortex as well) were evaluated for BBB leakage, BBB tight junction protein expression levels, activation of astrocytes, and microglia density using histological, immunostaining and immunoblotting techniques. We found that caffeine blocked high cholesterol diet-induced increases in extravasation of IgG and fibrinogen, increases in leakage of Evan's blue dye, decreases in levels of the tight junction proteins occludin and ZO-1, increases in astrocytes activation and microglia density where IgG extravasation was present. Chronic ingestion of caffeine protects against high cholesterol diet-induced increases in disruptions of the BBB, and caffeine and drugs similar to caffeine might be useful in the treatment of Alzheimer's disease.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 135 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Portugal 1 <1%
India 1 <1%
Colombia 1 <1%
Mexico 1 <1%
Canada 1 <1%
Unknown 127 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 17%
Researcher 20 15%
Student > Bachelor 20 15%
Student > Master 17 13%
Professor 9 7%
Other 29 21%
Unknown 17 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 24%
Medicine and Dentistry 25 19%
Neuroscience 15 11%
Biochemistry, Genetics and Molecular Biology 11 8%
Pharmacology, Toxicology and Pharmaceutical Science 6 4%
Other 21 16%
Unknown 24 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2020.
All research outputs
#1,012,043
of 18,787,703 outputs
Outputs from Journal of Neuroinflammation
#71
of 2,228 outputs
Outputs of similar age
#6,010
of 134,257 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 6 outputs
Altmetric has tracked 18,787,703 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,228 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 134,257 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them