@BellaLicher An den Unis sollten sie mal das hier lesen: https://t.co/AAF7dlsZAQ
RT @PadbergThorsten: @tonti_ef Aktueller Stand gut zusammengefasst: https://t.co/AAF7dlsZAQ Und was off-label so alles gezaubert wird, dar…
RT @PadbergThorsten: @tonti_ef Aktueller Stand gut zusammengefasst: https://t.co/AAF7dlsZAQ Und was off-label so alles gezaubert wird, dar…
@tonti_ef Aktueller Stand gut zusammengefasst: https://t.co/AAF7dlsZAQ Und was off-label so alles gezaubert wird, darf sich kaum evidenzbasiert nennen.
@MeretStoll @Cellarspectre @OliverBWeber Und selbst das ist inzwischen umstritten: https://t.co/AAF7dlsZAQ
13/ The max. 11% drug-plac diff fits well to the results of the big Cipriani et al. meta-analysis. They never reported it this way but only with odds-ratios, which seemed impressively large to some. In fact the diff in responders is also only ca. 10% https
@tvonw1 @ChristianThei18 @georg_henning @Psy_cholo @PadbergThorsten Als ich mir damals die S3 Leitlinien genauer angeschaut habe, musste ich fast was dazu schreiben, angesichts der offensichtlichen Mängel. https://t.co/HMZkDY2ZGD Ein Grund für mein Engagem
@markhoro @bell1_cara @Altostrata Table 2 contains the relevant info. https://t.co/xEgAc9hHWH
@allyrooney @PadbergThorsten @HengartnerMP This is a rather old one. Check out our overview of IPD studies (link below), and there is a real huge one to be published soon, with similar results https://t.co/xEgAc9hHWH
RT @PloederlM: @stephensenn We detected zombie statistics also in the current German treatment guidelines for depression https://t.co/X1hNB…
@stephensenn We detected zombie statistics also in the current German treatment guidelines for depression https://t.co/X1hNBIqaDl https://t.co/FhVuXiRjEW
@psychepi This is a slide from a recent talk. We published it here https://t.co/X1hNBIqaDl But we were not the first who came up with such a calculation, see here https://t.co/Whr63AJLyY
@awaisaftab Awais, thank you for pointing out these problems. When I read the German Depression guidelines, I felt we should do something for correction: https://t.co/HMZkDY2ZGD But this was met with much resistance in the review process that fits what you
@EdzardErnst Verm. (deutlich?) weniger als in med. Fachzeitschriften, oder? Wobei ich aus eigener Erfahrung sagen kann, dass unbequeme Ergebnisse (null/ gegenteilig) sehr schwer publizierbar sind, auch in guten Journals. Wir haben das in einem Fall mal mi
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
どのBL重症度であっても『3点』を「3点」と解釈することは議論の余地がありそうな気がする。 『この研究 [https://t.co/NdsCNDqqD1] では、事後的に患者を除外したにもかかわらず、#HDRS 群間差は全BL重症度に渡り一貫して3点差未満であった。』
4. Nearly all of my research is done in my leisure time. This way, I can create some safe space. See my declaration of interest for a critical discussion of the depression guidelines https://t.co/HMZkDY2ZGD https://t.co/6nJ9fjEXuF
@f_hieronymus @HengartnerMP @DrSaripanidis @EikoFried @sameerjauhar @JakobKaminski @CVolkmannMD @joannamoncrieff @JDaviesPhD @ReadReadj @DrDavidHealy @And_Cipriani Yes, the German DGPPN guidelines do when the evidence is discussed - and I think APA and NIC
@PloederlM @pharmademix @Altostrata @markhoro It's more complex than that. https://t.co/3WQNs7pY7D
@drsureshshah @sean_a_mcclure @engexplain @nntaleb More than that: I'm on the way of contributing to an upcoming guidline and I published this piece https://t.co/HMZkDY2ZGD See also Ioannidis' critical piece: https://t.co/gcBRmBQyVO And Cosgrove's impor
@psychunseen @awaisaftab Efficacy does not or only slightly increase with baseline severity https://t.co/xEgAc9hHWH There's sparse evidence for severely depressed psychiatric patients usually excluded in trials. Much uncertainty, but everybody is given on
RT @PloederlM: @callin_bull @HenryRunamucker @eturnermd1 Yes, you can start with that patient level analysis, but it seems you stopped with…
@callin_bull @HenryRunamucker @eturnermd1 Yes, you can start with that patient level analysis, but it seems you stopped with that ;-) Most new patient level MA found no or only minor increase of efficacy with baseline severity. See our 2019 review (Table 2
@johndrummond33 See here: https://t.co/xEgAc9hHWH
① その2009年 #コクラン・レビュー は #IPDメタ解析 ではない ② 2010年 #JAMA 掲載 #IPDメタ解析 が重症に対し #NICE 基準で有効性を主張した ③ 2011-18年に #IPDメタ解析 が9件公開され #NICE 基準では1件も有効性を示さず、1件が最重症に対し #プラセボ の優位性を示した https://t.co/KkItjFs26c https://t.co/XBBfo0CeaO
@pollyOh21 @HanschynS @schuler_jochen Noch was: gemäß S3-Leitlinien sind AD die first-line Behandl. nur bei mittl./schweren Depr. weil AD hier wirksamer sind (Risiken also vertretbar). Neue indiv.Pat.Daten zeigen aber keine Zunahme der Wirksamkeit mit dem
RT @Alex54749248: @awaisaftab @drsaeedassiri Thank you for balanced thread! Considering efficacy of AD for severe depression, what do you t…
@awaisaftab @drsaeedassiri Thank you for balanced thread! Considering efficacy of AD for severe depression, what do you think of this article of Plöderl and Hengartner? They criticise this point re German guidlines. Thanks! https://t.co/ELLEuWoB6L
RT @KellyMartin02: @ProfRobHoward @tiagofil79 @dranniehickox @jonathanstea Points out the flaws in suggesting AD efficacy: https://t.co/C…
@ProfRobHoward @tiagofil79 @dranniehickox @jonathanstea Points out the flaws in suggesting AD efficacy: https://t.co/Cy9dgmAFYn
@holmenkollin @Neuro24de @RNuebling @HengartnerMP Antworten sind in unserem Artikel, den ich eingangs erwähnte habe. https://t.co/uFxJ2p04bM
RT @Martin_Ploederl: @KonradHeiden Das glauben viele. Studienübersicht in Tab. 2 hier: https://t.co/uFxJ2phF3k Aber: zu schwer psych. bee…
@KonradHeiden Das glauben viele. Studienübersicht in Tab. 2 hier: https://t.co/uFxJ2phF3k Aber: zu schwer psych. beeinträchtigten komorbiden Psychiatrie-Patienten fehlt Evidenz! Man weiß dass Verläufe unter AD bei Komorbiditäten und Suizidalität weniger
RT @EvidenceFAB: @sushiattenoqol NICE Depression HAM-d 3point で検索の1ページ目に出ますよ。10年以上議論されています。 https://t.co/F0eXhrCEYn
@sushiattenoqol NICE Depression HAM-d 3point で検索の1ページ目に出ますよ。10年以上議論されています。 https://t.co/F0eXhrCEYn
@Foreman1David @johndrummond33 @DrEvgenyLegedin @peterkinderman @joannamoncrieff @rcpsych Oh, guidelines. So necessary bc how else should clinicians make evidence based tx decisions (impossible to read all studies). However, guidelines aren't free from COI
@tkaiser_science Re severity: I sent Francis the review of relevant data. Also, no robust predictor for treatment success in sight. If ADs will be found to really work for a subgroup, this would make bigger headlines than climate change, I guess. https://
@sanilrege @HengartnerMP @fredmagellan @SameiHuda @DrEvgenyLegedin Perhaps important 1. efficacy of AD doesn't increase (much) with severity https://t.co/HMZkDY2ZGD 2. the assumption of special responders is unlikely https://t.co/5Wk7HgW1PL
@AllenFrancesMD @DrEvgenyLegedin Where is solid data that antidepressents are especially working in acutely depressed psychiatric inpatients? AFAIK, we simply do not have solid data for these patients. Efficacy is not increasing (much) with depr. severety
@ChrisMeechan2 Would be interesting to hear where you see the most problematic parts of the guidance. And BTW, when I read the official psychiatric German guidelines for Depression, there was problematic advice, too, which has inspired us to write this pap
@DepressionHeute @WDR Gut, dass Dr. Heinz Stellung bezieht. Erwähnt ist auch die "oppositional tolerance". Leider kommt das Argument, AD nur bei schweren Depressionen zu verwenden, weil nur dort ein Vorteil ggü Placebo gefunden wurde. Das ist mittlerweile
#松崎朝樹 の #誤解 『#うつ病 の #メランコリー な亜型に対し、#抗うつ薬 がより効果的ではないことが判明した – #メランコリア型 は、#抑うつ点数 が高いことと関連しており、多くの専門家から #最重度 の #うつ病 とみなされている[https://t.co/zftqsAD49D]。』 https://t.co/fRPD3w2GuW
Just released from .@Twitter '#prorogation'; celebrating by re-sending early tweets:
@Martin_Ploederl @HengartnerMP @BioMedCentral @US_FDA @RANZCP 患者レベルのメタ解析の大半が、特に近頃の大規模メタ解析は、#重度うつ病 に対してでさえも、#抗うつ薬 が #プラセボ よりも #臨床的有意 に優れていないこと(#抗うつ薬 対 #プラセボ の群間差が #HAMD で3点未満)を報告した、と結論付けることができる。 https://t.co/6xHF6vqjWW https://t.co/PSwanRJpn0
RT @Martin_Ploederl: @AllenFrancesMD @GoldfriedMarvin Antidepressants do not achieve clinically significant effects across the whole range…
RT @Martin_Ploederl: @AllenFrancesMD @GoldfriedMarvin Antidepressants do not achieve clinically significant effects across the whole range…
@AllenFrancesMD @GoldfriedMarvin Antidepressants do not achieve clinically significant effects across the whole range of depression severity - see our review of patient level trial data https://t.co/HMZkDY2ZGD
大うつ病のための薬理学的急性治療のガイドライン:現在の科学的根拠と矛盾したドイツのS3ガイドライン 2019/9 @Martin_Ploederl @HengartnerMP #BMC_Psychiatry @BioMedCentral #抗うつ薬 #うつ病 #無料PMC記事 https://t.co/fRPD3w2GuW https://t.co/XYYNVEE6ta
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @LilSugarpill: 2019 research: "AD...marginally superior...in...depression...clinical significance of this small drug-placebo-difference…
2019 research: "AD...marginally superior...in...depression...clinical significance of this small drug-placebo-difference is questionable...the modest efficacy is likely an overestimation of the true efficacy" https://t.co/Dv1Y6nrCFl #TryHomeopathy #Because
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
Guidelines for the pharmacological acute treatment of major depression: conflicts with current evidence as demonstrated with the German S3-guidelines | BMC Psychiatry | Full Text https://t.co/l6wcJBDb8P
RT @drbergerdr: Just out, another honest article about “antidepressants” true nature vs. published guidelines: “Correcting the discrepancie…
RT @drbergerdr: Just out, another honest article about “antidepressants” true nature vs. published guidelines: “Correcting the discrepancie…
Just out, another honest article about “antidepressants” true nature vs. published guidelines: “Correcting the discrepancies between the content of the guidelines and current evidence is of utmost importance to avoid potentially harming patients.” https://
RT @DrMcFillin_PsyD: Another must read. Follow the science. Safety First. #ethics #evidencebasedpractice #evidence #MentalHealthMonday #Cbt…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @Stuartw99132233: #MentalHealthAwareness #depression #MentalHealthMonday Psych drugs are fraudulent neuro toxins https://t.co/a9skhj…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @DrMcFillin_PsyD: Another must read. Follow the science. Safety First. #ethics #evidencebasedpractice #evidence #MentalHealthMonday #Cbt…
Another must read. Follow the science. Safety First. #ethics #evidencebasedpractice #evidence #MentalHealthMonday #Cbtworks #psychworks #Somepsychs #depression
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
Essential, urgent understanding @jeremycorbyn @johnmcdonnellMP @LauraPidcockMP @labourlewis @RichardBurgon @UKLabour #PrescribedHarm #PublicInquiry
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
Required reading for mental health professionals. #depression #Psychotherapy #Psychology
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
Why do journals refuse publication?
RT @Stuartw99132233: #MentalHealthAwareness #depression #MentalHealthMonday Psych drugs are fraudulent neuro toxins https://t.co/a9skhj…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
#MentalHealthAwareness #depression #MentalHealthMonday Psych drugs are fraudulent neuro toxins
RT @Martin_Ploederl: 1/5 Guidelines for the pharmacological tx of depression. Conflicts with evidence & ignorance of biases - demonstrated…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…
RT @CEP_UK: Another excellent paper by @Martin_Ploederl & @HengartnerMP. They look at the German guidelines for depression treatment and fi…