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Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis

Overview of attention for article published in BMC Cancer, January 2012
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  • Average Attention Score compared to outputs of the same age

Mentioned by

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1 tweeter

Citations

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33 Dimensions

Readers on

mendeley
56 Mendeley
Title
Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis
Published in
BMC Cancer, January 2012
DOI 10.1186/1471-2407-12-44
Pubmed ID
Authors

Seung Joon Lee, Sigrid A Langhans

Abstract

Curcumin (diferuloylmethane), the yellow pigment in the Asian spice turmeric, is a hydrophobic polyphenol from the rhizome of Curcuma longa. Because of its chemopreventive and chemotherapeutic potential with no discernable side effects, it has become one of the major natural agents being developed for cancer therapy. Accumulating evidence suggests that curcumin induces cell death through activation of apoptotic pathways and inhibition of cell growth and proliferation. The mitotic checkpoint, or spindle assembly checkpoint (SAC), is the major cell cycle control mechanism to delay the onset of anaphase during mitosis. One of the key regulators of the SAC is the anaphase promoting complex/cyclosome (APC/C) which ubiquitinates cyclin B and securin and targets them for proteolysis. Because APC/C not only ensures cell cycle arrest upon spindle disruption but also promotes cell death in response to prolonged mitotic arrest, it has become an attractive drug target in cancer therapy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Indonesia 1 2%
Brazil 1 2%
India 1 2%
Canada 1 2%
Unknown 51 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 23%
Researcher 9 16%
Student > Master 9 16%
Student > Postgraduate 7 13%
Professor > Associate Professor 5 9%
Other 10 18%
Unknown 3 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 36%
Chemistry 8 14%
Biochemistry, Genetics and Molecular Biology 8 14%
Medicine and Dentistry 6 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Other 5 9%
Unknown 5 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2012.
All research outputs
#8,692,325
of 13,877,211 outputs
Outputs from BMC Cancer
#2,550
of 5,299 outputs
Outputs of similar age
#67,481
of 121,723 outputs
Outputs of similar age from BMC Cancer
#1
of 1 outputs
Altmetric has tracked 13,877,211 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,299 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 121,723 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them