Title |
Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis
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Published in |
BMC Cancer, January 2012
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DOI | 10.1186/1471-2407-12-44 |
Pubmed ID | |
Authors |
Seung Joon Lee, Sigrid A Langhans |
Abstract |
Curcumin (diferuloylmethane), the yellow pigment in the Asian spice turmeric, is a hydrophobic polyphenol from the rhizome of Curcuma longa. Because of its chemopreventive and chemotherapeutic potential with no discernable side effects, it has become one of the major natural agents being developed for cancer therapy. Accumulating evidence suggests that curcumin induces cell death through activation of apoptotic pathways and inhibition of cell growth and proliferation. The mitotic checkpoint, or spindle assembly checkpoint (SAC), is the major cell cycle control mechanism to delay the onset of anaphase during mitosis. One of the key regulators of the SAC is the anaphase promoting complex/cyclosome (APC/C) which ubiquitinates cyclin B and securin and targets them for proteolysis. Because APC/C not only ensures cell cycle arrest upon spindle disruption but also promotes cell death in response to prolonged mitotic arrest, it has become an attractive drug target in cancer therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | 1% |
India | 1 | 1% |
Netherlands | 1 | 1% |
Canada | 1 | 1% |
Unknown | 74 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 19% |
Student > Master | 11 | 14% |
Researcher | 9 | 12% |
Student > Bachelor | 7 | 9% |
Student > Postgraduate | 7 | 9% |
Other | 16 | 21% |
Unknown | 13 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 28% |
Biochemistry, Genetics and Molecular Biology | 11 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
Chemistry | 7 | 9% |
Medicine and Dentistry | 6 | 8% |
Other | 10 | 13% |
Unknown | 15 | 19% |